2006-2020年中国乙型肝炎流行趋势和时空聚集性分析  

Incidence and spatiotemporal clustering of hepatitis B in China,2006-2020

作　　者：王磊[1,2] 刘娜[1,2] 杨宏[1,2] 王富珍[1,2] 张国民[1,2] 王华庆[1,2] Wang Lei;Liu Na;Yang Hong;Wang Fuzhen;Zhang Guomin;Wang Huaqing(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Center for Disease Control and Prevention,Beijing 102206,China;National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China)

机构地区：[1]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206 [2]中国疾病预防控制中心免疫规划中心,北京100050

出　　处：《中华流行病学杂志》2025年第3期410-417,共8页Chinese Journal of Epidemiology

基　　金：北京自然科学基金-海淀原始创新联合基金(L212058)。

摘　　要：目的分析2006-2020年中国乙型肝炎(乙肝)流行趋势和时空聚集性特征,为乙肝防控工作提供参考依据。方法通过中国疾病预防控制信息系统传染病报告信息管理系统收集31个省(自治区、直辖市)2006-2020年乙肝报告病例数和发病率数据,应用Joinpoint 5.0.2软件进行时间趋势分析,应用SaTScan 10.1.2软件进行时空扫描分析,研究急性和慢性乙肝发病的流行趋势和时空聚集特征。结果2006-2020年全国共报告急性乙肝病例1049546例,年均报告发病率为5.17/10万,报告发病率呈下降趋势,其中0~岁组从3.00/10万下降至0.41/10万,15~岁组从14.15/10万下降至3.44/10万,≥35岁组从6.87/10万下降至3.72/10万,趋势变化有统计学意义(均P<0.001)。2006-2020年全国共报告慢性乙肝病例10732017例,年均报告发病率为52.85/10万,报告发病率在不同年龄组间变化趋势不同,其中0~岁组从11.38/10万下降至2.18/10万,15~岁组从73.17/10万下降至61.40/10万,而≥35岁组从48.07/10万上升至90.75/10万,趋势变化有统计学意义(均P<0.05)。时空扫描分析显示,急性乙肝报告发病年龄随时间向大龄组转移,高发地区从西部向西南转移。≥35岁慢性乙肝报告发病总体呈上升趋势,高发地区主要集中在东南沿海和西南地区。结论2006-2020年中国急性乙肝报告发病率总体呈持续下降趋势,≥35岁慢性乙肝报告发病呈上升趋势,需重点加强东南沿海和西南地区成年人慢性乙肝的诊治工作。Objective To analyze the incidence and spatiotemporal clustering of hepatitis B in China from 2006 to 2020 and provide reference for hepatitis B prevention and control.Methods The incidence data of hepatitis B in 31 provinces(autonomous regions and municipalities)from 2006 to 2020 were collected from National Notifiable Infectious Disease Reporting System of China Information System for Disease Control and Prevention.The incidence trend analysis was conducted by using software Joinpoint 5.0.2,and the spatiotemporal scan analysis was performed by using software SaTScan 10.1.2.Results From 2006 to 2020,a total of 1049546 cases of acute hepatitis B were reported in China.The average annual reported incidence rate was 5.17/100000.The reported incidence rate showed a decreasing trend during this period.The incidence decreased from 3.00/100000 to 0.41/100000 in age group 0-14 years,from 14.15/100000 to 3.44/100000 in age group 15-34 years,and from 6.87/100000 to 3.72/100000 in age group≥35 years,the differences were all significant(all P<0.001).From 2006 to 2020,a total of 10732017 cases of chronic hepatitis B were reported in China.The average annual reported incidence rate was 52.85/100000.The reported incidence of chronic hepatitis B varied in different age groups,which decreased from 11.38/100000 to 2.18/100000 in age group 0-14 years,and from 73.17/100000 to 61.40/100000 in age group 15-34 years,while increased from 48.07/100000 to 90.75/100000 in age group≥35 years,the differences were all significant(all P<0.05).Spatiotemporal scan analysis indicated that the age of reported acute hepatitis B cases became older over time,and the regions with high-incidence gradually shifted from western China to southwestern China.The overall reported incidence of chronic hepatitis B in those aged≥35 years showed an upward trend,and the regions with high-incidence were mainly found in coastal area in southeastern China and in southwestern China.Conclusions From 2006 to 2020,the overall reported incidence of acute hepatitis

关 键 词：乙型肝炎 乙型肝炎病毒 流行趋势 时空聚集性 

分 类 号：R51[医药卫生—内科学]