2017-2023年云南省德宏傣族景颇族自治州跨境婚姻人群HIV阳转率及影响因素分析  

Sero-conversion rate of HIV antibody and influencing factors in cross-border couples in Dehong Dai and Jingpo Autonomous Prefecture of Yunnan Province,2017-2023

作　　者：周群博 李晓晗 李林 杨跃诚 项丽芬 唐仁海 叶润华 王继宝 侯研 谢喜梅 许所菊 王龙钦 刘英[7] 丁盈盈[2] 何纳[2] 段松 Zhou Qunbo;Li Xiaohan;Li Lin;Yang Yuecheng;Xiang Lifen;Tang Renhai;Ye Runhua;Wang Jibao;Hou Yan;Xie Ximei;Xu Suoju;Wang Longqin;Liu Ying;Ding Yingying;He Na;Duan Song(Dehong Dai and Jinpo Autonomous Prefecture Center for Disease Control and Prevention,Mangshi 678400,China;Department of Epidemiology,Key Laboratory of Public Health Safety of Ministry of Education,School of Public Health,Fudan University,Shanghai 200032,China;Mangshi City Center for Disease Control and Prevention of Dehong Dai and Jingpo Autonomous Prefecture,Mangshi 678400,China;Ruili City Center for Disease Control and Prevention of Dehong Dai and Jingpo Autonomous Prefecture,Ruili 678600,China;Longchuan County Center for Disease Control and Prevention of Dehong Dai and Jingpo Autonomous Prefecture,Longchuan 678700,China;Yingjiang County Center for Disease Control and Prevention of Dehong Dai and Jingpo Autonomous Prefecture,Yingjiang 679300,China;Lianghe County Center for Disease Control and Prevention of Dehong Dai and Jingpo Autonomous Prefecture,Lianghe 679200,China)

机构地区：[1]德宏傣族景颇族自治州疾病预防控制中心,芒市678400 [2]复旦大学公共卫生学院流行病学教研室/公共卫生安全教育部重点实验室,上海200032 [3]德宏傣族景颇族自治州芒市疾病预防控制中心,芒市678400 [4]德宏傣族景颇族自治州瑞丽市疾病预防控制中心,瑞丽678600 [5]德宏傣族景颇族自治州陇川县疾病预防控制中心,陇川678700 [6]德宏傣族景颇族自治州盈江县疾病预防控制中心,盈江679300 [7]德宏傣族景颇族自治州梁河县疾病预防控制中心,梁河679200

出　　处：《中华流行病学杂志》2025年第3期455-461,共7页Chinese Journal of Epidemiology

基　　金：国家科技重大专项(2018ZX10715006-001,2018ZX10721102-004);国家重点地区艾滋病防治项目(卫办疾控发〔2004〕49号);国家重点研发计划(2022YFC2304902)。

摘　　要：目的了解云南省德宏傣族景颇族自治州(德宏州)跨境婚姻人群HIV阳转率及影响因素。方法采用队列研究设计,2017年招募德宏州跨境婚姻人群中基线HIV抗体阴性者为研究对象,于2023年进行研究对象的问卷调查和HIV检测的随访,计算HIV阳转率,采用单因素和多因素logistic回归模型分析该人群HIV阳转率的影响因素。结果研究对象为2017年德宏州跨境婚姻人群基线HIV抗体阴性者36278人,2023年随访22438人(61.9%),2017-2023年跨境婚姻人群的HIV阳转率为0.51%(115/22438)。多因素logistic回归模型分析结果显示,婚龄<6年、景颇族、小学及以下文化程度、有吸毒史、未办理结婚登记、配偶基线HIV阳性是男性HIV阳转的危险因素;婚龄<6年、景颇族、未办理结婚登记、配偶基线HIV阳性是女性HIV阳转的危险因素。结论德宏州跨境婚姻人群的HIV阳转率较高,主要感染途径为婚内二次传播,男性可能通过注射吸毒途径感染。应在跨境婚姻人群尤其是HIV单阳家庭中,持续加强婚姻登记的管理和吸毒的干预措施,降低跨境婚姻人群的婚内二次传播HIV的风险。Objective To investigate the sero-conversion rate of HIV antibody and influencing factors in cross-border couples in Dehong Dai and Jingpo Autonomous Prefecture(Dehong).Methods A cohort design was used to recruit HIV-negative people in cross-border couples in Dehong in 2017.Follow-up was conducted in 2023,and questionnaire survey and HIV test were carried out to calculate the sero-conversion rate of HIV antibody.Univariate and multivariate logistic regression models were used to analyze the influence factors for HIV infections.Results A total of 36278 HIV-negative persons in cross-border couples were included in the 2017 baseline survey,of whom 22438(61.9%)were tested in follow-up in 2023.The sero-conversion rate between 2017 and 2023 was 0.51%(115/22438).Multivariate logistic regression analysis showed that length of marriage<6 years,Jingpo ethnic group,education level of primary school or below,drug use,illegal marriage and HIV infected spouse were the risk factors of HIV infection in male spouses,and length of marriage<6 years,Jingpo ethnic group,illegal marriage and HIV infected spouse were the risk factors in female spouses.Conclusions The sero-conversion rate of HIV antibody in cross-border couples in Dehong was relatively high.HIV infection was mainly caused by secondary transmission in the couples,and men might also be infected through drug use.It is necessary to strengthen the registration and management of cross-border couples,especially the couples with discordant HIV infection status,and the intervention in drug users to reduce the risk for secondary transmission of HIV in the cross-border couples.

关 键 词：艾滋病病毒 阳转率 跨境婚姻人群 影响因素 

分 类 号：R51[医药卫生—内科学]