2011-2020年上海市辅助生殖技术治疗人群及子代流行病学特征分析  

Analysis on epidemiological characteristics of population receiving assisted reproductive technology therapy and their offspring in Shanghai,2011-2020

作　　者：虞慧婷[1,2] 崔欣 钱耐思 晋珊[1] 陈蕾 周峰 李琦[1] 蔡任之 王春芳[1] Yu Huiting;Cui Xin;Qian Naisi;Jin Shan;Chen Lei;Zhou Feng;Li Qi;Cai Renzhi;Wang Chunfang(Division of Public Health Informatics,Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;School of Public Health,Fudan University,Shanghai 200032,China;Shanghai Center for Health Statistics,Shanghai 200040,China)

机构地区：[1]上海市疾病预防控制中心疾病预防控制信息所,上海200336 [2]复旦大学公共卫生学院,上海200032 [3]上海市卫生健康统计中心,上海200040

出　　处：《中华流行病学杂志》2025年第3期484-491,共8页Chinese Journal of Epidemiology

基　　金：国家自然科学基金青年科学基金(82003486);上海市科技创新行动计划技术标准项目(22DZ2206000);上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科建设项目(GWVI-11.1-31,GWVI-11.1-35,GWVI-11.1-36)。

摘　　要：目的分析2011-2020年上海市辅助生殖技术(ART)治疗人群流行病学特征及子代出生特征变化趋势。方法基于上海市全人群出生队列,描述ART子代占出生总人数的比例及变化趋势,分析ART受孕和自然受孕人群户籍、文化程度、生育年龄和生育史的特征变化,并比较ART子代和自然受孕子代的健康差异。结果2011-2020年上海市共有ART子代70729例,占出生总人数的3.69%,2020年该比例达到7.79%。初育女性ART受孕比例高于再育女性,均呈上升趋势,2020年分别达到9.87%和2.36%。较高文化程度和上海市户籍女性ART受孕比例高于较低文化程度和非上海市户籍女性。ART单胎子代早产和低出生体重的发生率分别为7.76%和4.82%,高于自然受孕的4.69%和2.87%。ART双/多胎子代早产和低出生体重的发生率为56.98%和46.82%,低于自然受孕的58.51%和51.32%。结论社会人口特征差异在ART治疗中表现明显,提示部分人群在ART治疗需求上可能存在缺口,需要加强公共卫生服务建设,进一步扩大ART的覆盖范围和可及性。随着技术进步,早产和低出生体重率相对平稳,甚至在双/多胎中有所改善。Objective To analyze the epidemiological characteristics of the population receiving assisted reproductive technology(ART)therapy and the health status of their offspring in Shanghai from 2011 to 2020.Methods Based on the birth cohort of the entire population in Shanghai,the proportion and trend changes of ART offspring in the birth cohort were analyzed.The characteristics of ART and naturally conceived populations,including household registration,education level,maternal age,and reproductive history,were examined.Additionally,the health status between ART offspring and naturally conceived offspring were compared.Results From 2011 to 2020,a total of 70729 ART offspring were born in Shanghai,accounting for 3.69%of the total births.In 2020,this proportion reached 7.79%.The ART conception rate for primiparous women was higher than that for multiparous women,with both showing upward trends and reaching 9.87%and 2.36%,respectively,in 2020.The ART conception rate was higher in women with higher education levels and local household registration than in those with lower education levels and non-local household registration.The incidence rates of preterm birth and low birth weight in ART singleton offspring were 7.76%and 4.82%,respectively,higher than the 4.69%and 2.87%in naturally conceived offspring,but no increasing trend was observed in naturally conceived offspring.Among twin and multiple newborns,the incidence rates of preterm birth and low birth weight were 56.98%and 46.82%for ART,lower than the 58.51%and 51.32%for natural conception.Conclusions The difference in social and demographic characteristics was obvious in population receiving ART,suggesting that the differed demand of some people for ART therapy,and it is necessary to strengthen the construction of public health services and further expand the coverage and accessibility of ART services.With technological advancements,the rates of preterm birth and low birth weight remain relatively stable,and even decrease in twin and multiple newborns.

关 键 词：辅助生殖技术 生育年龄 早产 低出生体重 

分 类 号：R71[医药卫生—妇产科学]