中耳胆脂瘤骨破坏机制相关信号通路的研究进展  

Signaling pathways related to bone destruction mechanisms in middle ear cholestoeatoma

作　　者：邢丙文 席恺[2] 杨金焕 XING Bingwen;XI Kai;YANG Jinhuan(Clinical Medicine School of Henan University of Science and Technology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471003,China;Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471003,China;The Second Af filiated Hospital of Henan University of Science and Technology,HNHC Key Laboratary of Tissue Injury and Reapir Medicine,Luoyang,Henan 471000,China)

机构地区：[1]河南科技大学临床医学院河南科技大学第一附属医院,河南洛阳471003 [2]河南科技大学第一附属医院耳鼻咽喉头颈外科,河南洛阳471003 [3]河南科技大学第二附属医院河南省组织损伤与修复医学重点实验室,河南洛阳471000

出　　处：《中华实用诊断与治疗杂志》2025年第1期93-96,共4页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：中耳胆脂瘤具有侵袭性和骨破坏性,RANKL/RANK/OPG、NF-κB、酶介导的基质金属蛋白酶通路、炎症介质相关的Toll样受体和MAPK信号通路共同参与中耳胆脂瘤的骨破坏过程。探讨中耳胆脂瘤骨破坏机制中相关信号通路的调控机制和相互作用,对探索新的治疗方法具有重要意义。本文就中耳胆脂瘤骨破坏机制相关信号通路的研究进展作一综述。Middle ear cholesteatoma is characterized by invasiveness and bone destruction.RANKL/RANK/OPG pathway,NF-κB pathway,enzyme-mediated matrix metalloproteinases pathway,inflammation-related Toll-like receptor and mitogen-activated protein kinase signaling pathway,are all involved in the bone destruction process in middle ear cholesteatoma.To explore the regulatory mechanisms and interactions of these bone destruction-related signaling pathways may provide new strategies for the treatment of middle ear cholesteatoma.This paper reviews the research progress of signaling pathways involved in the bone destruction mechanisms of middle ear cholesteatoma.

关 键 词：中耳胆脂瘤 骨破坏机制 信号通路 

分 类 号：R764.2[医药卫生—耳鼻咽喉科]