黄蜀葵花化学成分、药理活性研究进展及质量标志物的预测分析  

Research progress in chemical constituents and pharmacological activities of Abelmoschi Corolla and prediction of its quality markers

作　　者：关诗涵 刘畅[1] 颜晓桐 韩金伟[1] 尹凤婷 孙晖[1] 闫广利[1] 孔玲[1] 韩莹[1] 王喜军[1] GUAN Shi-han;LIU Chang;YAN Xiao-tong;HAN Jin-wei;YIN Feng-ting;SUN Hui;YAN Guang-li;KONG Ling;HAN Ying;WANG Xi-jun(State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine,Chinmedomics Research Center of National Administration of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学、经方与现代中药融合创新全国重点实验室、国家中医药管理局中医方证代谢组学研究中心,黑龙江哈尔滨150040

出　　处：《中国中药杂志》2025年第4期908-921,共14页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(32141005)。

摘　　要：黄蜀葵花为锦葵科秋葵属植物黄蜀葵Abelmoschus manihot的干燥花冠,具有抗炎、抗氧化、抗纤维化等药理活性,其化学成分主要包括黄酮类、有机酸类、甾类、多糖类等。该研究对近20年来黄蜀葵花的化学成分、药理活性进行综述,并基于质量标志物(Q-marker)的概念,从植物亲缘性、化学成分特有性及可测性、传统药效、入血成分等方面对黄蜀葵花的质量标志物进行预测分析,初步预测槲皮素-3′-O-β-D-吡喃葡萄糖苷、棉皮素-8-O-β-D-葡萄糖醛酸苷、异槲皮素、杨梅素、槲皮素、金丝桃苷等可作为黄蜀葵花的质量标志物,旨在为完善黄蜀葵花的质量评价体系提供参考依据。Abelmoschi Corolla,the dried corolla of Abelmoschus manihot,has anti-inflammatory,antioxidant,and anti-fibrosis activities.Its chemical constituents mainly include flavonoids,organic acids,steroids,and polysaccharides.This study reviewed the research progress in the chemical constituents and pharmacological activities of Abelmoschi Corolla in recent 20 years.According to the concept of quality marker(Q-marker),the Q-markers of Abelmoschi Corolla were predicted from plant phylogeny,chemical constituent specificity,traditional efficacy,chemical constituent measurability,and absorbed constituents.The primary Q-markers for Abelmoschi Corolla were anticipated to include quercetin-3′-O-β-D-glucopyranoside,gossypetin-8-O-β-D-glucuronide,isoquercetin,myricetin,quercetin,and hyperoside,with the aim of providing reference data for improving the quality evaluation system of Abelmoschi Corolla.

关 键 词：黄蜀葵花 化学成分 药理活性 作用机制 质量标志物 

分 类 号：R28[医药卫生—中药学]