覆盆子化学成分、药理作用研究进展及其质量标志物预测分析  

Research progress on chemical constituents,pharmacological effects of Rubi Fructus and predictive analysis of its quality markers

作　　者：刘保松 余二伟 孙莹莹 宋耀宇 蒋可涵 宋亚刚 苗明三[3] 彭孟凡 LIU Bao-song;YU Er-wei;SUN Ying-ying;SONG Yao-yu;JIANG Ke-han;SONG Ya-gang;MIAO Ming-san;PENG Meng-fan(Preparation Room of Zhumadian Traditional Chinese Medicine Hospital,Zhumadian 463000,China;School of Medicine,Huanghuai University,Zhumadian 463000,China;NMPA Key Laboratory for Safety Research and Evaluation of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]驻马店市中医院制剂室,河南驻马店463000 [2]黄淮学院医学院,河南驻马店463000 [3]河南中医药大学国家药品监督管理局中药安全研究与评价重点实验室,河南郑州450046

出　　处：《中国中药杂志》2025年第4期922-933,共12页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82204679);国家药品监督管理局中药安全研究与评价重点实验室开放课题(SRETCM2024-04);河南省科技攻关项目(242102310523);河南省高等学校重点科研项目(25A360001)。

摘　　要：覆盆子在我国有着悠久的药用和食用历史,其含有萜类、黄酮类、酚酸类、脂肪酸类和生物碱类等化学成分,具有抗氧化、抗炎、降血糖、抗肿瘤、抗骨质疏松和保肝等多种药理活性,在医疗、保健、食品等领域具有广泛应用。覆盆子质量可直接影响临床用药的安全性和有效性,因此,该文综述了覆盆子化学成分和药理作用研究进展,并结合中药质量标志物(Q-marker)的概念,从植物亲缘性、传统功效、传统药性、化学成分可测性、不同加工炮制方法、不同产地、采收期和种植条件等方面探讨了覆盆子质量标志物的筛选与确定,初步推测出鞣花酸、山柰酚、槲皮素、山柰酚-3-O-芸香糖苷、芦丁、紫云英苷、椴树苷、金丝桃苷可作为覆盆子的质量标志物,为覆盆子质量控制提供参考。Rubi Fructus has a long history of medicinal and edible use in China.It contains chemical components such as terpenes,flavonoids,phenolic acids,fatty acids,and alkaloids,and possesses various pharmacological activities,including antioxidant,anti-inflammatory,hypoglycemic,anti-tumor,anti-osteoporosis,and liver-protective effects.Rubi Fructus is widely applied in medical,health,and food fields.The quality of Rubi Fructus can directly affect the safety and effectiveness of clinical medication.Therefore,this article reviews the research progress on the chemical constituents and pharmacological effects of Rubi Fructus.Based on the concept of traditional Chinese medicine(TCM)quality markers(Q-markers),the article explores the screening and determination of Q-markers for Rubi Fructus from various aspects,including plant kinship,traditional efficacy,medicinal properties,measurability of chemical composition,different processing methods,producing areas,harvesting periods,and planting conditions.The components ellagic acid,kaempferol,quercetin,kaempferol-3-O-rutinoside,rutin,astragalin,tiliroside,and hyperoside are preliminarily proposed as Q-markers for Rubi Fructus,providing a reference for the quality control of Rubi Fructus.

关 键 词：覆盆子 化学成分 药理作用 质量标志物 

分 类 号：R28[医药卫生—中药学]