硫辛酸联合丙硫氧嘧啶对甲状腺功能亢进症患者甲状腺功能及糖脂代谢的影响  

Effects of Alpha-Lipoic Acid Combined with Propylthiouracil on Thyroid Function and Glucose-Lipid Metabolism in Patients with Hyperthyroidism

作　　者：孙迪 贾佩 韦小年 SUN Di;JIA Pei;WEI Xiaonian(Department of Endocrinology and Metabolic Diseases,Qianhai Life Insurance Nanning Hospital,Nanning 530000,China)

机构地区：[1]前海人寿南宁医院内分泌代谢病科,南宁530000

出　　处：《微量元素与健康研究》2025年第2期10-14,共5页Studies of Trace Elements and Health

摘　　要：目的 观察硫辛酸联合丙硫氧嘧啶治疗甲状腺功能亢进症(简称甲亢)患者的疗效,并探讨其对甲亢患者甲状腺功能及糖脂代谢的影响。方法 选取2022年1月至2023年8月于本院诊治的104例甲亢患者开展回顾性分析,依据治疗方案分为对照组52例、观察组52例。对照组予以丙硫氧嘧啶治疗,观察组予以硫辛酸联合丙硫氧嘧啶治疗。比较两组疗效及治疗前后患者甲状腺功能、甲状腺体积、糖脂代谢、炎性反应因子、T淋巴细胞亚群的变化;比较两组不良反应与复发率。结果 观察组总有效率高于对照组(P<0.05);与对照组比较,观察组治疗后游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素受体抗体(TRAb)水平、甲状腺体积降低,促甲状腺素(TSH)水平升高(P<0.05);与对照组比较,观察组治疗后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平升高(P<0.05);两组治疗前后空腹血糖水平差异无显著性意义(P>0.05);与对照组比较,观察组治疗后血清内脂素(Visfatin)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平降低(P<0.05);与对照组比较,观察组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)升高(P<0.05);观察组治疗后6个月复发率低于对照组(P<0.05);两组不良反应比较差异无显著性意义(P>0.05)。结论 硫辛酸联合丙硫氧嘧啶治疗甲亢疗效确切,可改患者善甲状腺功能、血脂代谢,减小甲状腺体积,但其对糖代谢无明显影响,还可抑制炎性反应,改善机体免疫功能,降低复发率。Objective To observe the therapeutic efficacy of alpha-lipoic acid(ALA) combined with propylthiouracil(PTU) in the treatment of hyperthyroidism and to explore its effects on thyroid function and glucose-lipid metabolism.Methods A retrospective analysis was conducted on 104 patients with hyperthyroidism treated in our hospital from January 2022 to August 2023. According to the treatment regimen, they were divided into a control group(n=52) and an observation group(n=52). The control group received PTU alone, while the observation group was treated with ALA in combination with PTU. Clinical efficacy, thyroid function, thyroid volume, glucose-lipid metabolism, inflammatory markers, T-lymphocyte subsets, adverse reactions, and recurrence rates were compared between the two groups.Results The overall response rate in the observation group was significantly higher than that in the control group(P<0.05). Compared with the control group, the observation group showed lower levels of free triiodothyronine(FT3), free thyroxine(FT4), and thyrotropin receptor antibody(TRAb), as well as reduced thyroid volume, and higher levels of thyroid-stimulating hormone(TSH) after treatment(P<0.05). Serum total cholesterol(TC), triglycerides(TG), and low-density lipoprotein cholesterol(LDL-C) were significantly higher in the observation group than in the control group after treatment(P<0.05). There was no significant difference in fasting blood glucose levels before and after treatment between the two groups(P>0.05). Post-treatment levels of visfatin, interleukin-6(IL-6), and tumor necrosis factor-α(TNF-α) were lower in the observation group than in the control group(P<0.05). Meanwhile, CD3^(+), CD4^(+), and the CD4^(+)/CD8^(+) ratio were higher in the observation group than in the control group(P<0.05). The 6-month recurrence rate in the observation group was lower than in the control group(P<0.05). There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Alpha-lipoic acid combined with propylt

关 键 词：甲状腺功能亢进症 硫辛酸 丙硫氧嘧啶 甲状腺功能 糖脂代谢 

分 类 号：R581.1[医药卫生—内分泌]