Box-Behnken响应面法优化紫苏子配方颗粒提取工艺研究  

Study on optimization of the extraction process of Perillae fructus formula granules by Box-Behnken response surface methodology

作　　者：陆礼和 黄乐观 董文洁 杨燕 牛延菲 杨增明 胡弟强 冯莉萍 汤泮泮 LU Lihe;HUANG Leguan;DONG Wenjie;YANG Yan;NIU Yanfei;YANG Zengming;HU Diqiang;FENG Liping;TANG Panpan(Yunnan Institute of Materia Medica,Kunming 650111,China;Yunnan Provincial Key Laboratory for TCM and Ethnic Drug of New Drug Creation,Kunming 650111,China;Yunnan Baiyao Group Chinese Medicinal Resources Division,Kunming 650501,China)

机构地区：[1]云南省药物研究所,昆明650111 [2]云南省中药和民族药新药创制企业重点实验室,昆明650111 [3]云南白药集团中药资源有限公司,昆明650501

出　　处：《药学前沿》2025年第3期398-405,共8页China Pharmacist

基　　金：云南省重大科技专项(生物医药)(202002AA100007)。

摘　　要：目的优化紫苏子配方颗粒的提取工艺。方法在单因素试验基础上,以提取时间、料液比、提取次数为考察因素,迷迭香酸含量和出膏率为评价指标,采用Box-Behnken响应面法优化紫苏子配方颗粒的提取工艺,对浸膏粉进行干法制粒摸索。结果优化后的紫苏子配方颗粒制备工艺为加12倍量水煎煮90 min,减压浓缩、干燥制成浸膏粉,再加适量麦芽糊精、二氧化硅等,混匀后干法制粒,制得合格的紫苏子配方颗粒成品。结论优选的提取工艺简单、稳定、可行,为紫苏子配方颗粒工业化大生产提供依据。Objective To optimize the extraction process of Perillae fructus formula granules.Methods On the basis of single factor experiments,the extraction process of Perillae fructus formula granules was optimized using Box Behnken response surface methodology,with extraction time,solid-liquid ratio and extraction times as investigation factors,rosmarinic acid content and paste yield as evaluation indicators.The dry granulation of extract powder was explored.Results The optimized preparation process of Perillae fructus formula granules was as follows:boiling with 12 times the amount of water for 90 min,concentrating and dring under reduced pressure to produce paste powder,adding an appropriate amount of maltodextrin,silica,etc.,mixing well,dring to form granules,and producing qualified finished Perillae fructus formula granules.Conclusion The optimized preparation process is simple,stable and feasible,providing a basis for industrial production of Perillae fructus formula granules.

关 键 词：紫苏子 配方颗粒 Box-Behnken响应面法 提取工艺 

分 类 号：R284.1[医药卫生—中药学]