金钱胆通颗粒治疗慢性乙型肝炎合并慢性胆囊炎肝胆湿热证的临床研究  

Clinical study on jinqiandantong granules in the treatment of chronic hepatitis B complicated with chronic cholecystitis with damp-heat syndrome of liver and gallbladder

作　　者：吴眉[1] 万成怡 高月求[1] 杨婉凤[1] 李运东[1] 陶茹 WU Mei;WAN Chengyi;GAO Yueqiu;YANG Wanfeng;LI Yundong;TAO Ru(Department of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

机构地区：[1]上海中医药大学附属曙光医院肝病科,上海200021

出　　处：《药学前沿》2025年第3期437-443,共7页China Pharmacist

基　　金：国家中医药管理局高水平中医药重点学科建设项目(中医肝胆病学)(zyyzdxk-2023060)。

摘　　要：目的观察金钱胆通颗粒治疗慢性乙型肝炎合并慢性胆囊炎肝胆湿热证的疗效及安全性。方法采用随机、双盲的方式将慢性乙型肝炎合并慢性胆囊炎患者分为金钱胆通颗粒治疗组(试验组)和金钱胆通模拟剂组(对照组)。观察患者治疗前后疼痛评分、肝功能、肝脏和胆囊超声及中医证候积分。结果研究共纳入患者120例,试验组和对照组各60例。治疗后,试验组患者疼痛评分明显下降,且低于对照组(P<0.05);试验组患者谷氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、谷氨酰转肽酶(GGT)、总胆红素(TBil)、乙肝表面抗原(HBsAg)水平较治疗前显著下降(P<0.05),但ALT、AST、ALP、GGT、直接胆红素(DBil)、乙肝e抗原(HBeAg)水平与对照组差异无统计学意义(P>0.05),仅TBil和HBsAg水平低于对照组(P<0.05)。试验组3例由肝脏回声粗糙转为肝脏回声未见明显异常,43例由胆囊壁粗糙转为胆囊未见明显异常,试验组中医证候积分降低,且低于对照组(P<0.05),两组均无明显不良反应。结论金钱胆通颗粒可改善慢性乙型肝炎合并慢性胆囊炎患者肝胆湿热证临床症状、胆囊反射区疼痛,降低患者TBiL和HBsAg水平,且安全性良好。Objective To observe the efficacy and safety of Jinqian Dantong granules in the treatment of chronic hepatitis B complicated with chronic cholecystitis with damp-heat syndrome of liver and gallbladder.Methods A randomized,double-blind experiment was conducted to divide patients with chronic hepatitis B combined with chronic cholecystitis into the Jinqian Dantong granules treatment group(the experimental group)and the Jinqian Dantong simulant group(the control group).The pain scores,liver function,liver and gallbladder ultrasound and TCM syndrome scores of patients before and after treatment were observed.Results A total of 120 patients were included in the study,with 60 in each group.After treatment,the pain score of patients in the experimental group decreased significantly and was lower than that of the control group(P<0.05).The levels of alanine aminotransferase(ALT),alkaline phosphatase(ALP),glutamyltranspetidase(GGT),total bilirubin(TBil),and hepatitis B virus surface antigen(HBsAg)of patients in the experimental group were significantly lower than those before treatment(P<0.05),there was no significant difference in the levels of ALT,AST,ALP,GGT,direct bilirubin(DBil),and hepatitis B e antigen(HBeAg)between the experimental group and the control group(P>0.05),and only the levels of TBil and HBsAg in the experimental group were lower than those in the control group(P<0.05).Three people in the experimental group switched from rough liver echoes to liver echoes without obvious abnormalities,and 43 people switched from rough gallbladder wall to gallbladder without obvious abnormalities.The traditional Chinese medicine syndrome scores in the experimental group decreased and were lower than those in the control group(P<0.05),and there were no obvious adverse reactions in both groups.Conclusion Jinqian Dantong granules can improve clinical symptoms such as liver and gallbladder damp-heat syndrome and gallbladder reflex zone pain in patients with chronic hepatitis B combined with chronic cholecystitis,reduce TBiL a

关 键 词：金钱胆通颗粒 慢性胆囊炎 慢性乙型肝炎 临床疗效 安全性 随机对照试验 

分 类 号：R969[医药卫生—药理学]