甲硝唑氯霉素搽剂与小剂量异维A酸联用治疗面部寻常型痤疮的疗效观察  

The therapeutic effect of metronidazole chloramphenicol liniment combined with low-dose isotretinoin in the treatment of facial acne vulgaris

作　　者：归婵娟 刘盾 金彩飞 谭又吉 GUI Chanjuan;LIU Dun;JIN Caifei;TAN Youji(Department of Shangbai Inpatient,Zhejiang Provincial Dermatology Hospital,Huzhou 313200,Zhejiang Province,China;Nursing Department,Zhejiang Dermatology Hospital,Huzhou 313200,Zhejiang Province,China;Health Management Center,Zhejiang Dermatology Hospital,Huzhou 313200,Zhejiang Province,China)

机构地区：[1]浙江省皮肤病医院上柏住院部,浙江湖州313200 [2]浙江省皮肤病医院护理部,浙江湖州313200 [3]浙江省皮肤病医院健管中心,浙江湖州313200

出　　处：《药学前沿》2025年第3期466-471,共6页China Pharmacist

基　　金：2022年度湖州市科技计划项目(2022GY74)。

摘　　要：目的分析甲硝唑氯霉素搽剂与小剂量异维A酸软胶囊联用治疗面部寻常型痤疮的疗效。方法回顾性分析2023年6月至2024年6月于浙江省皮肤病医院门诊就诊的寻常型痤疮患者的临床资料。根据治疗方案不同分为对照组和研究组,对照组采用甲硝唑氯霉素搽剂治疗,研究组在此基础上联合小剂量维A酸软胶囊治疗。比较两组疗效、耐药性和治疗依从性情况、生活质量和不良反应。结果共纳入80例面部寻常型痤疮患者,每组各40例,研究组总有效率显著高于对照组(P<0.05)。两组患者治疗期间耐药率差异无统计学意义(P>0.05)。研究组依从性优良率显著高于对照组(P<0.05)。治疗后两组皮肤病生活质量指数各维度评分降低,研究组的瘙痒和疼痛、尴尬、社交和休闲、个人关系、治疗等维度分更低(P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论甲硝唑氯霉素搽剂联合小剂量异维A酸软胶囊治疗面部寻常型痤疮疗效更理想,可提升患者治疗依从性及生活质量,安全性良好。Objective To analyze the therapeutic effect of metronidazole chloramphenicol liniment combined with low-dose isotretinoin soft capsules on facial acne vulgaris.Methods The chinical data of patients with acne vulgaris who visited the outpatient department of Zhejiang Provincial Dermatology Hospital from June 2023 to June 2024 were retrospectively analyzed and divided into the control group and the study group according to different treatment strategies.The control group was treated with metronidazole chloramphenicol liniment,and on this basis,the study group was treated with low-dose isotretinoin soft capsules.The efficacy,drug resistance and treatment compliance,quality of life and adverse reactions in the two groups were compared.Results a total of 80 patients were included,with 40 in each group.The study group demonstrated a significantly higher total effective rate compared to the control group(P<0.05).There was no significant difference in drug resistance between the two groups during treatment(P﹥0.05).The excellent and good rate of treatment compliance in the study group was higher than that in the control group(P<0.05).After treatment,the scores of each dimension of the quality of life index for dermatology of the two groups decreased,however,the study group exhibited significantly lower scores in specific dimensions,including itching,pain,embarrassment,social and leisure activities,personal relationships,and treatment-related concerns(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P﹥0.05).Conciusion Metronidazole chloramphenicol liniment combined with low-dose isotretinoin soft capsules achieved better efficacy in the treatment of facial acne vulgaris,improved patient compliance and quality of life,and demonstrated good safety.

关 键 词：异维A酸软胶囊 甲硝唑氯霉素搽剂 寻常型痤疮 疗效 生活质量 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]