槲皮素与器官缺血再灌注损伤研究进展  

Research progress on quercetin and organ ischemia/reperfusion injury

作　　者：董静宇[1] 王闻渤 刘洋 李娜[1] DONG Jingyu;WANG Wenbo;LIU Yang;LI Na(Department of Anesthesiology,The Second Hospital&Clinical Medical School,Lanzhou University,Lanzhou 730000,China;Endoscopy Center,The Second Hospital&Clinical Medical School,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院(第二临床医学院)麻醉手术科,兰州730030 [2]兰州大学第二医院(第二临床医学院)内镜中心,兰州730030

出　　处：《药学前沿》2025年第3期506-515,共10页China Pharmacist

基　　金：甘肃省自然科学基金项目(22JR11RA049)。

摘　　要：缺血/再灌注(I/R)损伤会导致活性氧(ROS)和促炎细胞因子增加,引起细胞死亡并加重器官功能损伤。天然植物化合物槲皮素具有抗氧化、抗炎、抗肿瘤等多种药物活性。本综述展示了槲皮素通过影响多种分子途径(如Toll样受体4、核因子κB、磷脂酰肌醇3-激酶/蛋白激酶B等)和凋亡相关蛋白(B淋巴细胞瘤-2基因、胱天蛋白酶),降低ROS水平及抑制炎症反应,在多器官I/R损伤中的保护作用。并指出了槲皮素在联合应用、纳米粒子制剂、提高生物利用率以及临床试验方面的未来研究方向,为槲皮素减轻I/R损伤提供了新的思路和策略。Ischemia reperfusion(I/R)injury leads to an increase in reactive oxygen species(ROS)and pro-inflammatory cytokines,resulting in cell death and exacerbating organ dysfunction.The natural plant compound quercetin exhibits various pharmacological activities,including antioxidant,anti-inflammatory,and anti-tumor effects.This review demonstrates that quercetin exerts protective effects against multi-organ I/R injury by influencing various molecular pathways(such as TLR4,NF-κB,PI3K/Akt)and apoptotic proteins(Bcl-2,Caspases),reducing ROS levels,and suppressing inflammatory responses.Future research directions,including combination therapy,nanoparticle formulations,improving bioavailability,and clinical trials,are also outlined,providing new insights and strategies for mitigating I/R injury with quercetin.

关 键 词：槲皮素 缺血再灌注损伤 研究进展 信号通路 

分 类 号：R966[医药卫生—药理学]