肝移植围手术期感染及抗菌策略  

Perioperative infection and antibacterial strategies in liver transplantation

作　　者：俞淼 杜航 王文华 黄钰茹 YU Miao;DU Hang;WANG Wenhua;HUANG Yuru(Department of Pharmacy,Chongqing Fifth People's Hospital,Chongqing 400062,China;Department of Pharmacy,The Affiliated Dazu’s Hospital of Chongqing Medical University,Chongqing 402360,China)

机构地区：[1]重庆市第五人民医院药剂科,重庆400062 [2]重庆医科大学附属大足医院药剂科,重庆402360

出　　处：《药学前沿》2025年第3期525-530,共6页China Pharmacist

基　　金：重庆市大足区科技发展项目(DZKJ2022JSYJ-KWXM1017)。

摘　　要：肝移植受者由于自身基础疾病及术后需常规采用免疫抑制剂抗排斥,通常免疫力低下,极易围手术期感染。而细菌和真菌感染是肝移植后高死亡率的主要原因,故加强预防肝移植术后感染极为重要。目前肝移植围手术期预防感染方案还未达成共识,本文针对肝移植围手术期感染的易感因素、常见感染部位和病原菌种类及相关抗菌策略作简要综述,以期为肝移植围手术期抗菌药物的预防性应用提供参考。Liver transplant recipients often have low immunity due to their underlying diseases and the need for routine use of immunosuppressants to resist rejection after surgery,making them highly susceptible to perioperative infections.Bacterial and fungal infections are the main causes of high mortality after liver transplantation,so it is extremely important to strengthen the prevention of infection after liver transplantation.At present,there is no consensus on the prevention of infection during the perioperative period of liver transplantation.This article provides a brief review of the susceptibility factors,common infection sites,types of pathogens,and related antibacterial strategies for perioperative infection in liver transplantation,to provide reference for the prevention and use of antibiotics during the perioperative period of liver transplantation.

关 键 词：肝移植 围手术期 感染 抗菌药物 免疫抑制剂 

分 类 号：R978.1[医药卫生—药品]