联合检测EB病毒抗体对鼻咽癌的临床诊断价值分析  

Analysis of the Clinical Diagnostic Value of Combined Detection of EB Vi⁃rus Antibodies for Nasopharyngeal Carcinoma

作　　者：刘启波[1] 梅闯闯 黎翠翠[1] LIU Qibo;MEI Chuangchuang;LI Cuicui(Department of Clinical Laboratory,Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou 510095,Guangdong,China)

机构地区：[1]广东省第二中医院检验科,广东广州510095

出　　处：《系统医学》2024年第24期104-106,110,共4页Systems Medicine

摘　　要：目的分析EB病毒抗体联合检测诊断鼻咽癌的价值。方法回顾性选取2020年8月—2021年1月就诊于广东省第二中医院的鼻咽癌患者(31例)及同期健康体检人员(96名)的临床资料。鼻咽癌患者为鼻咽癌组,健康体检人员为健康对照组。受试者均接受VCA-IgA、EA-IgA、Rta-IgG、NA1-IgA检测。分析单一指标与联合指标检测的诊断价值。结果鼻咽癌组EB病毒的血清VCA-IgA、EA-IgA、Rta-IgG、NA1-IgA阳性检出率高于健康对照组,差异有统计学意义(P均<0.05)。联合检测的准确度、灵敏度、阳性预测值、阴性预测值为96.9%(123/127)、90.3%(28/31)、96.6%(28/29)、96.9%(95/98),均高于各单一指标诊断,差异有统计学意义(P均<0.05)。结论EB病毒抗体可以有效地筛查鼻咽癌,EB病毒抗体联合检测可以有效提高诊断效能。Objective To analyze the clinical diagnostic value of the combined detection of EB virus antibodies for na‐sopharyngeal carcinoma.Methods The clinical data of thirty-one patients with nasopharyngeal carcinoma admitted to Guangdong Second Traditional Chinese Medicine Hospital from August 2020 to January 2021 and ninety-six healthy physical examination subjects in the same period were retrospectively selected.Patients with nasopharyngeal carci‐noma were the nasopharyngeal carcinoma group,and the healthy physical examination subjects were the healthy con‐trol group.All subjects underwent detections of VCA-IgA,EA-IgA,Rta-IgG,and NA1-IgA.The diagnostic values of single-index and combined-index detections were analyzed.Results The positive detection rates of serum VCA-IgA,EA-IgA,Rta-IgG,and NA1-IgA of EB virus in the nasopharyngeal carcinoma group were higher than those in the healthy control group,differences were statistically significant(all P<0.05).The accuracy,sensitivity,positive predic‐tive value,negative predictive value of the combined detection were 96.9%(123/127),90.3%(28/31),96.6%(28/29),96.9%(95/98),respectively,which were all higher than those of each single-index diagnosis,differences were statisti‐cally significant(all P<0.05).Conclusion EB virus antibodies can effectively screen for nasopharyngeal carcinoma,and EB virus antibodies combined detection can improve diagnostic efficacy.

关 键 词：联合检测 EB病毒抗体 鼻咽癌 

分 类 号：R446[医药卫生—诊断学]