妊娠高血压综合征疾病诊断中应用凝血四项与血浆D-二聚体的诊断价值分析  

Analysis of the Combined Diagnostic Value of Coagulation Function and Plasma D-dimer in the Diagnosis of Pregnational Hypertension Syndrome

作　　者：孟宪林 刘静 崔明双 MENG Xianlin;LIU Jing;CUI Mingshuang(Department of Clinical Laboratory,Beijing Fangshan District Maternal and Child Health Care Hospital,Beijing 102488,China;Department of Gynaecology and Obstetrics,Beijing Fangshan District Maternal and Child Health Care Hospital,Beijing 102488,China)

机构地区：[1]北京市房山区妇幼保健院检验科,北京102488 [2]北京市房山区妇幼保健院妇产科,北京102488

出　　处：《系统医学》2024年第24期161-163,171,共4页Systems Medicine

摘　　要：目的 分析凝血四项、血浆D-二聚体单一指标检测与联合检测对妊娠高血压综合征(简称妊高征)患者的诊断效能。方法 非随机选取北京市房山区妇幼保健院2023年1月—2023年4月收治的45例确诊妊娠高血压孕妇为发生组,选取同期55名行健康体检孕妇为未发生组。分别对两组进行凝血四项、血浆D-二聚体检测,分析凝血四项、血浆D-二聚体单一指标检测与联合检测的检验效能。结果 发生组凝血酶原时间、活化部分凝血酶原时间、凝血酶时间均低于未发生组,发生组纤维蛋白原、血浆D-二聚体高于未发生组,差异有统计学意义(P均<0.05)。联合检验敏感度为93.33%(42/45)、特异度为92.73%(51/55)、准确度为93.00%(93/100),其中准确度高于凝血四项的81.00%(81/100)和D-二聚体的87.00%(87/100),三者比较,差异有统计学意义(χ^(2)=6.366,P<0.05)。结论 妊娠高血压综合征患者疾病诊断中采用凝血四项与血浆D-二聚体联合诊断的诊断效能较高。Objective To analyze the diagnostic efficacy of coagulation function,plasma D-dimer single index detec‐tion and combined detection of patients with pregnan-induced hypertension syndrome(PIH).Methods Forty-five hy‐pertensive pregnancy women in Beijing Fangshan Maternal and Child Health Hospital from January 2023 to April 2023 were non-randomly selected as the occurrence group,and fifty-five pregnant women who underwent physical ex‐amination during the same period were selected as the non-occurrence group.Coagulation function and plasma D-dimer were detected respectively in two groups,and the efficacy of coagulation function and plasma D-dimer single in‐dex detection and combined detection were analyzed.Results Prothrombin time,activated partial thromboplastin time and thrombin time in the occurrence group were lower than those in the non-affected group,the fibrinogen and plasma D-dimer in occurrence group were higher than those in non-affected group,the differences were statistically signifi‐cant(all P<0.05).The sensitivity,specificity and accuracy of the combined test were 93.33%(42/45),92.73%(51/55)and 93.00%(93/100),and the accuracy was higher than 81.00%(81/100)and 87.00%(87/100)of the coagulation function and plasma D-dimer,and the difference was statistically significant(χ^(2)=6.366,P<0.05).Conclusion The combination of coagulation function and plasma D-dimer tests in the diagnosis of pregnational hypertension syndrome have higher diagnostic efficacy.

关 键 词：凝血四项 血浆D-二聚体 灵敏度 特异度 检验效能 联合检验 

分 类 号：R4[医药卫生—临床医学]