宫颈鳞状细胞癌中肿瘤浸润淋巴细胞与瘤芽关系的研究进展  

Research Progress on the Mechanism of Melatonin in the Prevention and Treatment of Osteoporosis

作　　者：董洁 张锦玉 DONG Jie;ZHANG Jinyu(Department of General Medicine,Affiliated Hospital of Yanbian University,Yanji 133000,Jilin,China)

机构地区：[1]延边大学附属医院全科医学科,吉林延吉133000

出　　处：《系统医学》2024年第24期190-194,共5页Systems Medicine

基　　金：2020年度梅州市社会发展科技计划项目(2020B095)。

摘　　要：近年来,宫颈鳞状细胞癌中的肿瘤浸润淋巴细胞(tumor infiltrating lymphocytes, TILs)与瘤芽之间的研究成为肿瘤微环境领域的前沿课题,受到广泛关注。本文细评述了TILs在肿瘤微环境中的作用机制,分析了其与肿瘤细胞的交互作用模式。这些免疫细胞不仅通过直接的细胞毒性作用影响肿瘤细胞,还通过分泌细胞因子调节肿瘤微环境,相应地影响瘤芽的形成与发展。本文归纳了TILs与瘤芽在宫颈鳞状细胞癌进展中的协同效应,探讨了二者共同参与的免疫调控路径。同时,分析了将TILs和瘤芽作为联合靶点的研究前景,指出通过调节这两种病理指标的新型免疫治疗策略的潜力。针对性地调控TILs的浸润及瘤芽的形成,可能成为提高宫颈鳞状细胞癌治疗效果的重要方向。本研究旨在为未来深入探索TILs和瘤芽的作用机制及其在肿瘤治疗中的应用奠定了基础。With the increasing aging of the population,the number of osteoporosis patients is increasing,making the re‐search on the prevention and treatment of this condition increasingly urgent.Melatonin has certain significance for the prevention and treatment of osteoporosis,but there is a lack of specific analysis of the mechanism of melatonin on osteopo‐rosis.This article systematically describes the effects of melatonin on the mechanism of osteoporosis by antioxidant,endo‐crine,immunomodulatory,and microscopic regulation.These results show that melatonin affects the mechanism of osteo‐porosis through various effects,so as to prevent the occurrence and development of osteoporosis,and provide a certain ref‐erence for the in-depth development of melatonin anti-osteoporosis research.

关 键 词：宫颈鳞状细胞癌 肿瘤浸润淋巴细胞 瘤芽 

分 类 号：R4[医药卫生—临床医学]