早期2型糖尿病患者发生肾病的影响因素分析  

Influencing Factors of Nephropathy in Patients with Early Type 2 Diabetes Mellitus

作　　者：黄钦强 卢志玲 陈锦凤 HUANG Qinqiang;LU Zhiling;CHEN Jinfeng(Department of Endocrinology and MetabolismⅡ,Zhangzhou Affiliated Hospital of Fujian Medical University,Zhangzhou 363000,Fujian,China;Department of Emergency Medicine,Longwen Branch,Zhangzhou Affiliated Hospital of Fujian Medical University,Zhangzhou 363000,Fujian,China)

机构地区：[1]福建医科大学附属漳州市医院内分泌代谢二科,福建漳州363000 [2]福建医科大学附属漳州市医院龙文分院急诊科,福建漳州363000

出　　处：《糖尿病新世界》2025年第3期16-18,22,共4页Diabetes New World

摘　　要：目的探讨早期2型糖尿病(type 2 diabetes mellitus,T2DM)患者发生糖尿病肾病(diabetic nephropathy,DN)的影响因素。方法回顾性选取2020年1月-2023年12月就诊于福建医科大学附属漳州市医院内分泌代谢二科确诊为早期T2DM的220名患者的临床资料。根据有无发生DN分为DN组(34例)和非DN组(186例)。对两组患者临床资料进行单因素分析和多因素COX回归分析,分析早期T2DM患者发生DN的影响因素。结果两组高血压史、基础空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇、甘油三酯、治疗方式比较,差异均有统计学意义(P均<0.05)。多因素COX回归分析结果显示,胰岛素强化治疗是早期T2DM患者发生DN的独立保护因素(P<0.05);糖化血红蛋白≥6%、总胆固醇≥5.2 mmol/L、甘油三酯≥1.7 mmol/L均是早期T2DM患者发生DN的独立危险因素(P均<0.05)。结论胰岛素强化治疗、糖化血红蛋白、总胆固醇、甘油三酯均是早期T2DM患者发生DN的影响因素。Objective To investigate the influencing factors of diabetic nephropathy(DN)in patients with early type 2 diabetes mellitus(T2DM).Methods The clinical data of 220 patients diagnosed with early T2DM in Department of En-docrinology and MetabolismⅡof Zhangzhou Hospital Affiliated to Fujian Medical University from January 2020 to December 2023 were retrospectively selected.According to the presence or absence of DN,they were divided into DN group(34 cases)and non-DN group(186 cases).Univariate analysis and multivariate COX regression analysis were performed on the clinical data of the two groups to analyze the influencing factors of DN in patients with early T2DM.Results There were significant differences in hypertension history,basic fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin A1c,total cholesterol,triglyceride and treatment methods between the two groups(all P<0.05).Multivariate COX regression analysis results showed that intensive insulin therapy,is an independent protective factor for DN in patients with early T2DM(P<0.05);glycated hemoglobin A1c≥6%,total cholesterol≥5.2 mmol/L and triglyceride≥1.7 mmol/L were independent risk factors for DN in patients with early T2DM(all P<0.05).Conclusion Intensive insulin therapy,glycated hemoglobin A1c,total cholesterol and triglyceride are the influencing factors of DN in patients with early T2DM.

关 键 词：2型糖尿病 糖尿病肾病 胰岛素强化治疗 危险因素 

分 类 号：R587.2[医药卫生—内分泌]