探究不同病情程度糖尿病足感染患者血清炎症因子水平及血清CRP、Cys-C水平变化的临床意义  

Clinical Significance of Changes of Serum Inflammatory Factors,Serum CRP and Cys-C Levels in Patients with Diabetic Foot Infection of Different Severity

作　　者：苏慧娜 姚小杰 赵婷 林淑君[3] SU Huina;YAO Xiaojie;ZHAO Ting;LIN Shujun(Department of Clinical Laboratory,Zhangzhou Hospital,Zhangzhou 363000,Fujian,China;Department of Rheumatology and Immunology,Zhangzhou Hospital,Zhangzhou 363000,Fujian,China;Department of Oncology,Zhangzhou Hospital,Zhangzhou 363000,Fujian,China)

机构地区：[1]漳州市医院检验科,福建漳州363000 [2]漳州市医院风湿免疫科,福建漳州363000 [3]漳州市医院肿瘤内科,福建漳州363000

出　　处：《糖尿病新世界》2025年第3期42-45,共4页Diabetes New World

摘　　要：目的探究不同病情程度糖尿病足感染患者血清炎症因子及C反应蛋白(C-reactive protein,CRP)、胱抑素C(cystatin-C,Cys-C)水平变化的临床意义。方法纳入2022年2月-2023年2月漳州市医院收治的120例糖尿病足患者,根据是否发生感染分为感染组(n=73)和未感染组(n=47);并根据感染严重程度将感染组分为轻度感染组(n=23)、中度感染组(n=24)和重度感染组(n=26);并选取同期40例健康体检者作为对照组。比较组间血清炎症因子及CRP、Cys-C水平,分析各指标与糖尿病足感染严重程度的相关性。结果感染组血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、降钙素原(procalcitonim,PCT)、CRP、Cys-C水平均高于未感染组及对照组,差异均有统计学意义(P均<0.05)。重度感染组血清hs-CRP、TNF-α、IL-6、PCT、CRP、Cys-C水平均高于中度感染组及轻度感染组,差异均有统计学意义(P均<0.05)。hs-CRP、TNF-α、IL-6、PCT、CRP、Cys-C水平与糖尿病足感染严重程度呈正相关。结论血清hs-CRP、TNF-α、IL-6、PCT、CRP、Cys-C在糖尿病足感染中均呈高表达,且随感染程度的加重而升高,以上炎症因子指标可作为判断糖尿病足是否存在感染和炎症严重性的依据。Objective To explore the clinical significance of changes in serum inflammatory factors,C-reactive pro-tein(CRP)and cystatin-C(Cys-C)levels in patients with diabetic foot infection of different severity.Methods A total of 120 patients with diabetic foot admitted to Zhangzhou Hospital from February 2022 to February 2023 were enrolled.According to whether infection occurred,they were divided into infection group(n=73)and non-infection group(n=47).According to the severity of infection,the infection group was divided into mild infection group(n=23),moderate infection group(n=24)and severe infection group(n=26).At the same time,40 healthy subjects were selected as the control group.The levels of serum inflammatory factors,CRP and Cys-C were compared between the groups,and the correlation between each index and the severity of diabetic foot infection was analyzed.Results The levels of serum hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),procalcitonin(PCT),CRP and Cys-C in the infection group were higher than those in the non-infection group and the control group,and the differences were statistically significant(all P<0.05).The levels of serum hs-CRP,TNF-α,IL-6,PCT,CRP and Cys-C in severe infection group were higher than those in moderate infection group and mild infection group,and the differences were statistically significant(all P<0.05).The levels of serum hs-CRP,TNF-α,IL-6,PCT,CRP and Cys-C were positively correlated with the severity of diabetic foot infection.Conclusion Serum hs-CRP,TNF-α,IL-6,PCT,CRP and Cys-C were highly expressed in diabetic foot infection,and increased with the severity of infection.Therefore,the above inflammatory factor indicators can be used as a basis for judging whether there is infection and inflammation in diabetic foot.

关 键 词：糖尿病足 感染 血清炎症因子 C反应蛋白 胱抑素-C 

分 类 号：R587.2[医药卫生—内分泌]