T2DM认知障碍国内外研究进展  

Progress in Domestic and International Research on Cognitive Impairment in T2DM

作　　者：林茵如 陈弼沧[2] 吴秋英[3] 杨源杰 LIN Yinru;CHEN Bicang;WU Qiuying;YANG Yuanjie(Department of Endocrinology,Xiamen Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine,Xiamen 361000,Fujian,China;Department of Constitution Adjustment,Quanzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine,Quanzhou 362000,Fujian,China;Department of Encephalopathy,Quanzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine,Quanzhou 362000,Fujian,China)

机构地区：[1]福建中医药大学附属厦门中医院内分泌科,福建厦门361000 [2]福建中医药大学附属泉州市中医院体质调理科,福建泉州362000 [3]福建中医药大学附属泉州市中医院脑病科,福建泉州362000

出　　处：《糖尿病新世界》2025年第3期185-187,191,共4页Diabetes New World

摘　　要：2型糖尿病(type 2 diabetes mellitus,T2DM)患者常伴胰岛素抵抗,会损害神经元及脑功能,影响认知能力。鉴于此,本文将综述T2DM与认知障碍的关联,探讨血糖水平、胰岛素抵抗、炎症、氧化应激、糖化终产物、共存疾病、大脑结构变化和基因相关性等潜在机制,并在治疗方面,强调生活方式干预、药物治疗、中医治疗等综合方案的可行性。Patients with type 2 diabetes mellitus(T2DM)are often accompanied by insulin resistance,which can dam-age neurons and brain function and affect cognitive ability.In view of this,this article will review the association be-tween T2DM and cognitive impairment,and explore potential mechanisms such as blood glucose levels,insulin resis-tance,inflammation,oxidative stress,advanced glycation end products,coexisting diseases,brain structural changes,and genetic correlation.In terms of treatment,it emphasizes the feasibility of comprehensive programs such as lifestyle intervention,drug treatment,and traditional Chinese medicine treatment.

关 键 词：2型糖尿病 认知障碍 糖尿病神经病变 治疗方案 

分 类 号：R587.2[医药卫生—内分泌]