中性粒细胞/淋巴细胞比值、血清25-羟基维生素D与1型糖尿病的研究进展  

Research Progress of Neutrophil/Lymphocyte Ratio,Serum 25-Hydroxyvi⁃tamin D and Type 1 Diabetes Mellitus

作　　者：薛堰方 刘俊祥[1] XUE Yanfang;LIU Junxiang(Department of Endocrinology,Ordos Central Hospital,Ordos 017002,Inner Mongolia Autonomous Region,China)

机构地区：[1]鄂尔多斯市中心医院内分泌科,内蒙古鄂尔多斯017002

出　　处：《糖尿病新世界》2025年第2期189-193,198,共6页Diabetes New World

摘　　要：1型糖尿病(type 1 diabetes mellitus,T1DM)作为一种自身免疫性疾病,其发病率呈稳步上升趋势,具有免疫调节作用的血清25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]不仅参与T1DM的发生发展,并对其并发症也起到预防保护作用。大量研究表明中性粒细胞/淋巴细胞比值(neutrophil/lymphocyte ratio,NLR)作为新型的炎症和氧化应激标记物,对T1DM的诊断评估和预后预测具有较大意义。本文旨在分析NLR、血清25(OH)D与T1DM的研究进展。As an autoimmune disease,the incidence of type 1 diabetes mellitus(T1DM)is steadily increasing.Serum 25-hydroxyvitamin D[25(OH)D],which has immunomodulatory effects,is not only involved in the occurrence and development of T1DM,but also plays a preventive and protective role in its complications.A large number of studies have shown that neutrophil/lymphocyte ratio(NLR),as a new marker of inflammation and oxidative stress,is of great significance for the diagnosis and prognosis of T1DM.This article aims to analyze the research progress of NLR,se-rum 25(OH)D and T1DM.

关 键 词：1型糖尿病 血清25-羟基维生素D 中性粒细胞/淋巴细胞比值 

分 类 号：R587.1[医药卫生—内分泌]