Zero-P椎间融合固定术后早期应用补阳还五汤治疗神经根型颈椎病疗效分析  

Analysis of early application of Buyang Huanwu Decoction after Zero-P interbody fusion fixation of Buyang Huanwu Decoction in the treatment of cervical spondylosis

作　　者：黄导 谢添 彭红玲 李曙波 袁俊 HUANG Dao;XIE Tian;PENG Hong-ling;LI Shu-bo;YUAN Jun(Department of Orthopaedics and TraumatologyⅢ,Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430014;Department of Orthopaedics,Wuhan Hospital of Integrative Medicine and Orthopaedics,Wuhan 430079,Hubei,China)

机构地区：[1]武汉市中医医院·湖北中医药大学附属国医医院骨伤3科,湖北武汉430014 [2]武汉中西医结合骨科医院骨内科,湖北武汉430079

出　　处：《川北医学院学报》2025年第3期336-339,共4页Journal of North Sichuan Medical College

基　　金：湖北省武汉市中医药科研项目(WZ22A09)。

摘　　要：目的:观察Zero-P椎间融合固定术后早期应用补阳还五汤治疗神经根型颈椎病临床疗效。方法:纳入拟行Zero-P手术的90例神经根型颈椎病患者为研究对象,按照治疗方式分为对照组(单纯Zero-P手术,n=45)与治疗组(Zero-P术后早期应用补阳还五汤,服用1个月,n=45),比较两组患者术前、术后1周、1、3个月疼痛视觉模拟评分(VAS)、颈椎功能障碍指数(NDI)、中医证候积分,检测并比较术前、术后1周、1个月肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)及白细胞介素-6(IL-6)水平。结果:两组患者术后1周、1个月、3个月疼痛VAS评分、NDI评分及中医证候积分随时间推移降低(P<0.05),且治疗组术后各时间点均低于对照组(P<0.05);两组患者术后1周、1个月TNF-α、IL-1β及IL-6水平随时间推移降低(P<0.05),且治疗组各时间点均低于对照组(P<0.05)。结论:Zero-P椎间融合固定术后早期应用补阳还五汤治疗神经根型颈椎病能够降低炎性反应,显著改善疼痛、恢复颈椎功能,促进术后康复。Objective:To analyze the clinical efficacy of early application of Buyang Huanwu Decoction after Zero-P intervertebral fusion fixation surgery in the treatment of cervical spondylotic radiculopathy.Methods:90 patients with cervical spondylotic radiculopathy who underwent the Zero-P procedure were divided into two groups based on treatment methods:the control group(underwent Zero-P surgery alone,n=45) and the treatment group(received Buyang Huanwu Decoction early after Zero-P surgery for one month,n=45).The visual analog scale(VAS),cervical dysfunction index(NDI),and traditional Chinese medicine syndrome score of pain were compared between two groups before surgery and at 1 w,1 m,and 3 m after surgery.The levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6) were measured and compared before surgery and at 1 w,1 m post-surgery.Results:The VAS scores,NDI scores,and TCM syndrome scores of both groups at 1 w,1 m,and 3 m after surgery were lower than those before surgery(P<0.05),and the degree of reduction increased over time(P<0.05).The treatment group showed more significant reductions at corresponding time points compared to the control group(P<0.05).Both groups showed decreases in TNF-α,IL-1β,and IL-6 levels at 1 w and 1 m after surgery compared to before surgery(P<0.05),and the treatment group showed lower levels at corresponding time points compared to the control group(P<0.05).Conclusion:Early application of Buyang Huanwu Decoction after Zero-P interbody fusion fixation can reduce inflammatory response,significantly improve pain,restore cervical function,and accelerate recovery in patients with cervical radiculopathy.

关 键 词：Zero-P系统 颈前路融合 神经根型颈椎病 补阳还五汤 术后康复 

分 类 号：R242[医药卫生—中医临床基础]