桂枝茯苓胶囊联合地诺孕素治疗子宫内膜异位症的疗效及对患者PAF、TGF-β1水平的影响  

Efficacy of combination of Guizhi Fuling capsule and dienogest on endometriosis and influence on levels of PAF and TGF-β1

作　　者：张蕾 樊雅芝 赵晓娟 ZHANG Lei;FAN Ya-zhi;ZHAO Xiao-juan(Department of Gynecology,the First People s Hospital of Xianyang,Xianyang 712000,Shaanxi,China)

机构地区：[1]咸阳市第一人民医院妇科,陕西咸阳712000

出　　处：《川北医学院学报》2025年第3期344-348,共5页Journal of North Sichuan Medical College

基　　金：陕西省咸阳市重点研发计划项目(S2022-ZDYF-SF-1062)。

摘　　要：目的:探究桂枝茯苓胶囊联合地诺孕素(DNG)治疗子宫内膜异位症(EMT)的疗效及其对EMT患者血小板活化因子(PAF)、转化生长因子-β1(TGF-β1)水平的影响。方法:选取98例EMT患者作为研究对象,根据不同的治疗方法分为DNG组(n=45,接受DNG治疗)和联合组(n=53,接受桂枝茯苓胶囊联合DNG治疗)。比较两组患者治疗3个月经周期后的临床疗效,治疗前后的中医证候积分、PAF、TGF-β1水平、血液流变学、血流动力学指标、视觉模拟量表(VAS)评分。结果:治疗后,联合组的疗效优于DNG组(P<0.05);两组中医证候积分、PAF、TGF-β1、血浆黏度、红细胞压积、红细胞沉降率水平、VAS评分均较同组治疗前降低(P<0.05),且联合组均低于DNG组(P<0.05);两组最大血流速度均较同组治疗前升高(P<0.05),且联合组高于DNG组(P<0.05),搏动指数、阻力指数均较同组治疗前降低(P<0.05),且联合组均低于DNG组(P<0.05)。结论:DNG联合桂枝茯苓胶囊治疗EMT较单用DNG更有效,且能降低患者血清PAF和TGF-β1水平,有效抑制炎症反应,改善子宫血流,能更好的控制病情并减缓疾病进程。Objective:To explore the efficacy of Guizhi Fuling capsule combined with dinogest(DNG) in the treatment of endometriosis(EMT) and influence on levels of platelet activating factor(PAF) and transforming growth factor-β1(TGF-β1) in patients with EMT.Methods:98 patients with EMT were retrospectively studied.According to different treatment methods,they were divided into DNG group(n=45,DNG treatment) and combined group(n=53,Guizhi Fuling capsule combined with DNG treatment).The clinical efficacy after 3 menstrual cycles of treatment and TCM syndromes scores,PAF and TGF-β1,hemorheology,hemodynamic indicators and visual analogue scale(VAS) score before and after treatment were compared between groups.Results:After treatment,the efficacy in combined group was better than that in DNG group(P<0.05).The TCM syndromes scores,PAF,TGF-β1,plasma viscosity,hematocrit,erythrocyte sedimentation rate and VAS score in the two groups were decreased compared to before treatment(P<0.05),and the above indicators were lower in combined group(P<0.05).The maximum blood flow velocity was increased in both groups compared with that before treatment(P<0.05),and the velocity in combined group was faster(P<0.05),and pulsatility index and resistance index were reduced compared to before treatment(P<0.05),and the combined group had lower pulsatility index and resistance index(P<0.05).Conclusion:DNG combined with Guizhi Fuling capsule is more effective than DNG alone in treating EMT,and it can reduce the levels of serum PAF and TGF-β1,effectively inhibit the inflammatory response,improve the uterine blood flow,control the disease condition and slow down the disease process.

关 键 词：子宫内膜异位症 地诺孕素 桂枝茯苓胶囊 血小板活化因子 转化生长因子-β1 

分 类 号：R711.71[医药卫生—妇产科学]