B族链球菌感染对妊娠晚期阴道微生态情况与妊娠结局的影响研究  

Influence of group B streptococcus infection on vaginal microecology and pregnancy outcomes in late pregnancy

作　　者：吴海红[1] 桑琳[1] 王润秋[1] 李涛 WU Hai-hong;SANG Lin;WANG Run-qiu;LI Tao(Department of Obstetrics and Gynecology,the Second People's Hospital of Hefei City,Hefei 230011,Anhui,China)

机构地区：[1]合肥市第二人民医院妇产科,安徽合肥230011

出　　处：《川北医学院学报》2025年第3期362-365,共4页Journal of North Sichuan Medical College

基　　金：安徽省高校自然科学基金项目(KJ2020A0217)。

摘　　要：目的:探讨B族链球菌(GBS)感染对妊娠晚期阴道微生态情况与妊娠结局的影响。方法:回顾性分析行产前阴道分泌物检查的120例晚期孕妇的临床资料,根据GBS感染检测结果分为GBS阳性组(n=71)和GBS阴性组(n=49)。比较两组阴道微生态失衡情况、阴道清洁度分级、孕妇分娩方式、孕妇与围产儿不良妊娠结局。结果:GBS阳性组细菌性阴道病(BV)发生率、阴道微生态失衡率及阴道pH值>4.6患者占比均高于GBS阴性组(P<0.05);GBS阳性组阴道清洁度分级为1度患者占比低于GBS阴性组(P<0.05),3度、4度患者占比高于GBS阴性组(P<0.05);GBS阳性组孕妇自然阴道分娩率低于GBS阴性组(P<0.05),中转剖宫产率高于GBS阴性组(P<0.05);GBS阳性组孕妇不良妊娠结局(宫内感染、胎膜早破、羊水浑浊/污染及产褥感染)与围产儿不良结局(早产、胎儿窘迫、肺炎、GBS感染)发生率均高于GBS阴性组(P<0.05)。结论:GBS感染对妊娠晚期阴道微生态平衡状况和阴道清洁度有一定影响,可增加孕妇不良妊娠结局与围产儿不良结局风险。Objective:To investigate the influence of group B streptococcus(GBS) infection on vaginal microecology and pregnancy outcomes in late pregnancy.Methods:Retrospective study on clinical data of late pregnant women who received prenatal vaginal secretion examination were selected for the study.According to the GBS infection detection results,they were divided into GBS positive group(n=71) and GBS negative group(n=49).The vaginal microecological imbalance,vaginal cleanliness grading,delivery modes of pregnant women,adverse pregnancy outcomes of pregnant women and perinatal infants were compared between groups.Results:The incidence rate of bacterial vaginosis(BV),vaginal microecological imbalance rate and proportion of patients with vaginal pH value>4.6 in GBS positive group were higher than those in GBS negative group(P<0.05).The proportion of patients with vaginal cleanliness grade 1 in GBS positive group was lower than that in GBS negative group(P<0.05) while the proportions of patients with grade 3 and grade 4 were higher(P<0.05).The rate of natural vaginal delivery in GBS positive group was lower(P<0.05) while the rate of conversion to cesarean section was higher compared with that in GBS negative group(P<0.05).The incidence rates of adverse pregnancy outcomes of pregnant women(intrauterine infection,premature rupture of membranes,amniotic fluid turbidity/pollution and puerperal infection) and perinatal adverse outcomes(premature birth,low birth weight,pneumonia,GBS infection) were higher in GBS positive group than those in GBS negative group(P<0.05).Conclusion:GBS infection has a certain impact on vaginal microecological balance and vaginal cleanliness in late pregnancy,which can increase the risk of adverse pregnancy outcomes and perinatal adverse outcomes.

关 键 词：妊娠晚期 B族链球菌 阴道微生态 妊娠结局 

分 类 号：R714.25[医药卫生—妇产科学]