乙哌立松联合艾瑞昔布对关节镜下前交叉韧带重建术患者的临床疗效  

Clinical efficacy of eperisone combined with imrecoxib in patients undergoing arthroscopic anterior cruciate ligament reconstruction

作　　者：田伯友 宋阳 赵小魁 董巍 杨敬 王强 TIAN Bo-you;SONG Yang;ZHAO Xiao-kui;DONG Wei;YANG Jing;WANG Qiang(Department of Orthopedics,Emergency General Hospital,Beijing 100028,China)

机构地区：[1]应急总医院骨科,北京100028

出　　处：《川北医学院学报》2025年第3期366-369,399,共5页Journal of North Sichuan Medical College

基　　金：应急总医院医学发展科研基金项目(K202105)。

摘　　要：目的:探讨乙哌立松联合艾瑞昔布对关节镜下前交叉韧带重建术患者的临床疗效。方法:将120例前交叉韧带损伤患者根据治疗方式不同分为对照组及观察组,每组各60例。所有患者均行关节镜下前交叉韧带重建术治疗,对照组术后采用艾瑞昔布治疗;观察组在对照组基础上联合乙哌立松治疗,连续治疗1个月。记录并比较两组患者治疗有效率、首次下床时间、住院时间、首次屈膝90°时间、疼痛程度、炎症及膝关节功能。结果:观察组患者治疗有效率高于对照组(P<0.05);首次下床时间、住院时间及首次屈膝90°时间均短于对照组(P<0.05)。术后1、3及6个月,两组患者视觉疼痛模拟评分表(VAS)评分均随时间逐渐降低(P<0.05),且观察组均低于对照组(P<0.05)。治疗后,观察组和对照组患者的超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平均降低(P<0.05),且观察组均低于对照组(P<0.05)。两组患者治疗后国际膝关节文献委员会(IKDC)主观评分、Lysholm及Tegner水平评分均较治疗前升高(P<0.05),且观察组均高于对照组(P<0.05)。结论:乙哌立松联合艾瑞昔布治疗可促进行关节镜下前交叉韧带重建术患者术后恢复,利于缓解关节疼痛,有助于降低炎症反应及改善膝关节功能,值得临床推荐使用。Objective:To investigate the clinical efficacy of eperisone combined with imrecoxib in patients undergoing arthroscopic anterior cruciate ligament reconstruction.Methods:120 patients with anterior cruciate ligament injur were divided into a control group and an observation group according to the different treatment approaches,with 60 cases in each group.All patients underwent arthroscopic anterior cruciate ligament reconstruction.Post-operatively,the control group was treated with imrecoxib,while the observation group received eperisone in addition to the control group?s treatment.Both groups continued their respective treatments for 1 month.The treatment efficiency,first time out of bed,hospitalization time,first time to bend the knee at 90°,pain level,inflammation and knee function of the two groups were recorded and compared.Results:The effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The levels of first time out of bed,length of hospitalization and time to first 90° knee flexion were lower in the observation group than in the control group(P<0.05).Visual Analogue Scale(VAS) scores in both groups decreased at 1,3,and 6 months post-operation compared to pre-treatment levels(P<0.05),and the observation group was lower than the control group(P<0.05).Post-treatment levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α) decreased in both groups,with lower levels observed in the observation group compared to the control group(P<0.05).International Knee Documentation Committee(IKDC) subjective scores,Lysholm knee scores,and Tegner activity scores increased in both groups after treatment,with higher scores recorded in the observation group compared to the control group(P<0.05).Conclusion:Treatment with eperisone in combination with imrecoxib promotes postoperative recovery in patients undergoing arthroscopic anterior cruciate ligament reconstruction,facilitates the relief of joint pain,helps to reduce the in

关 键 词：乙哌立松 艾瑞昔布 前交叉韧带重建 关节镜 疗效 

分 类 号：R687.4[医药卫生—骨科学]