右美沙芬愈创甘油醚糖浆联合阿奇霉素治疗对肺炎支原体肺炎患儿心肌酶、凝血功能及炎症的影响  

Effect of dextromethorphan guaifenesin syrup combined with azithromycin on myocardial enzymes,coagulation function,and inflammation in children with Mycoplasma pneumoniae pneumonia

作　　者：张悦 徐美超 张学斌 ZHANG Yue;XU Mei-chao;ZHANG Xue-bin(Department of Pediatrics,Pinggu Hospital,Beijing Friendship Hospital,Capital Medical University,Beijing 101200,China)

机构地区：[1]首都医科大学附属北京友谊医院平谷医院儿科,北京101200

出　　处：《川北医学院学报》2025年第3期375-379,共5页Journal of North Sichuan Medical College

基　　金：北京市平谷区医院科研项目(pgyy2024-08)。

摘　　要：目的:探究右美沙芬愈创甘油醚糖浆联合阿奇霉素治疗对肺炎支原体肺炎患儿心肌酶、凝血功能及炎症的影响。方法:选取88例肺炎支原体患儿为研究对象,按照治疗方法不同分为两组,每组各44例。对照组采用阿奇霉素治疗;联合组采用右美沙芬愈创甘油醚糖浆联合阿奇霉素治疗,两组均治疗7 d。比较治疗后两组患儿临床症状缓解情况,心肌酶谱和肝功能[乳酸脱氢酶(LDH)、肌酸激酶(CK)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)]、凝血功能[D-二聚体(D-D)及纤维蛋白原(Fbg)]及炎症指标[C反应蛋白(CRP)、降钙素原(PCT)、中性粒细胞百分比(NEU)、白细胞(WBC)及血小板(PLT)]水平,记录并比较治疗疗效及不良反应发生情况。结果:联合组咳嗽、发热及肺部湿啰音的消退时间均较对照组缩短(P<0.05)。治疗后,两组患儿LDH、CK、AST及ALT水平,D-D及Fbg水平,CRP、PCT、NEU、WBC及PLT水平均较治疗前下降,且联合组低于对照组(P<0.05)。两组除Fbg下降幅度差异无统计学意义(P>0.05),其余指标差异均有统计学意义(P<0.05)。联合组治疗有效率高于对照组(P<0.05)。两组患儿不良反应总发生率差异无统计学意义(P>0.05)。结论:右美沙芬愈创甘油醚与阿奇霉素联合治疗法在儿童肺炎支原体肺炎中疗效显著,不仅有效缓解患儿临床症状,还可减少心肌损害和肝功能损伤,改善凝血功能,同时抑制炎症反应,安全性较高,值得临床推广应用。Objective:To investigate the effects of dextromethorphan guaifenesin syrup combined with azithromycin on myocardial enzymes,coagulation function,and inflammation in children with mycoplasma pneumoniae pneumonia.Methods:88 children with mycoplasma pneumonia were divided into a control group and a combination group according to different treatment methods,with 44 cases in each group.The control group received treatment with azithromycin,while the combination group was treated with dextromethorphan guaifenesin syrup in conjunction with azithromycin,with both groups undergoing treatment for 7 days.The clinical symptom relief between the two groups of children after treatment,as well as the levels of myocardial enzyme spectrum and liver function [lactate dehydrogenase(LDH),creatine kinase(CK),aspartate aminotransferase(AST),alanine aminotransferase(ALT)],coagulation function [D-dimer(D-D) and fibrinogen(Fbg)],and inflammatory indicators [C-reactive protein(CRP),procalcitonin(PCT),neutrophil percentage(NEU),white blood cells(WBC),and platelets(PLT)],along with the treatment efficacy and occurrence of adverse reactions were compared between the two groups.Results:The time for the resolution of cough,fever,and lung moist rales in the combined treatment group was shorter than that in the control group(P<0.05).After treatment,the levels of LDH,CK,AST,and ALT,as well as D-D and Fbg levels,and the levels of CRP,PCT,NEU,WBC,and PLT in both groups of children decreased compared to before treatment,with the decrease in the combined treatment group being more pronounced than that in the control group(P<0.05).The decrease of Fbg in the combined group was greater than that in the control group,but the difference was not statistically significant(P>0.05).The treatment efficiency of the combined group was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups of children compared to each other(P>0.05).Conclusion:The combination of dextromethorpha

关 键 词：右美沙芬愈创甘油醚糖浆 阿奇霉素 肺炎支原体肺炎 患儿 心肌酶 

分 类 号：R725.6[医药卫生—儿科]