耳鸣与脑鸣患者静息态功能磁共振成像分析  

Analysis of resting state functional magnetic resonance imaging in patients with tinnitus and tinnitus cranii

作　　者：张树帆 吴碧华[1] ZHANG Shu-fan;WU Bi-hua(Department of Geriatrics,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院老年医学科,四川南充637000

出　　处：《川北医学院学报》2025年第3期385-388,共4页Journal of North Sichuan Medical College

摘　　要：目的:使用静息态功能磁共振成像技术(rs-fMRI)分析脑鸣和耳鸣局部脑功能变化及脑区之间功能连接变化的差异,为耳鸣的诊断及分类提供新思路。方法:纳入20例脑鸣患者为脑鸣组;20例耳鸣患者为耳鸣组,收集其临床资料及静息态功能磁共振数据。利用Matlab 2021b平台的SPM 12软件与DPABI 6.3进行数据处理;计算并比较组间ReHo、FC等指标的差异。结果:脑鸣组右侧中央前回/中央后回的ReHo值高于耳鸣组(P<0.05)。脑鸣组左侧前扣带回与右侧颞下回、右侧岛盖部额下回、右侧中央前回/中央后回之间的功能连接低于耳鸣组(P<0.05),脑鸣组左侧楔前叶与右侧缘上回之间的功能连接低于耳鸣组(P<0.05)。结论:耳鸣和脑鸣患者之间的脑区神经活动及脑区之间的功能连接存在差异,这可能与患者对幻听的空间感知不同有关。Objective:Using resting state functional magnetic resonance imaging(rs-fMRI) analysis tinnitus cranii and tinnitus local brain function changes and functional connection between brain areas of difference,provide new way for the diagnosis and classification of tinnitus.Methods:This study included 20 patients with tinnitus cranii,20 patients with tinnitus,and collected their clinical data and RS-fMRI data.The SPM 12 software of Matlab 2021b platform and DPABI 6.3 toolkit were used to analyze the data.The differences of ReHo and FC among the groups were calculated.Results:The ReHo value of the right central sulci in the tinnitus cranii group was higher than that in the tinnitus group(P<0.005).The functional connections between the left anterior cingulate gyrus and the right inferior temporal gyrus,the right inferior frontal gyrus of the insular cap and the right central sulci gyrus in the tinnitus cranii group were lower than those in the tinnitus group,and the functional connections between the left anterior cuneus and the right superior marginal gyrus in the tinnitus cranii group were lower than those in the tinnitus group.Conclusion:There are differences in neural activity and functional connections between brain regions between tinnitus and tinnitus cranii patients,which may be related to the different spatial perception of auditory hallucinations.

关 键 词：耳鸣 脑鸣 功能磁共振 局部一致性 

分 类 号：R445.2[医药卫生—影像医学与核医学]