基于Meta分析有氧运动与心血管疾病患者心脏功能、脂质代谢和炎症的关联性  

Meta Analysis of the Correlation between Aerobic Exercise and Cardiac Function,Lipid Metabolism,and Inflammation in Patients with Cardiovascular Disease

作　　者：张国栋[1] 魏思昂 高金霞[4] 何晖 潘峰[4] 谢艳丽[1] ZHANG Guo-dong;WEI Si-ang;GAO Jin-xia;HE Hui;PAN Feng;XIE Yan-li(Department of Physical Education,Shanxi Agricultural University,Taigu 030801,China;College of Life Sciences,Shanxi Agricultural University,Taigu 030801,China;Zhongshan Hospital Affiliated to Fudan University,Shanghai 200032,China;College of Physical Education,Sichuan University,Chengdu 610065,China)

机构地区：[1]山西农业大学体育部,太谷030801 [2]山西农业大学生命科学学院,太谷030801 [3]复旦大学附属中山医院,上海200032 [4]四川大学体育学院,成都610065

出　　处：《科学技术与工程》2025年第9期3604-3612,共9页Science Technology and Engineering

基　　金：国家体育科普基地(GJTK024);国家自然科学基金(81700256)。

摘　　要：为探索有氧运动与心血管疾病患者心脏功能、脂质代谢和炎症关联性,通过检索PubMed、Embase、Scopus和中国知网(CNKI)数据库中有氧运动与心血管疾病患者心脏功能、脂质代谢和炎性因子影响的相关研究,利用RevMan5.4和R软件进行Meta和关联性分析。结果表明:有氧运动显著降低了B型利钠肽(B-type natriuretic peptide,BNP)[标准化均数差(standardized mean difference,SMD)=-0.84,95%CI(-1.34,-0.34),P=0.001]、收缩压(SBP)[SMD=-0.55,95%CI(-0.86,-0.25),P=0.0004]和舒张压(DBP)[SMD=-0.99,95%CI(-1.67,-0.32),P=0.004]、LDL[SMD=-0.53,95%CI(-0.89,-0.18),P=0.003]和C-反应蛋白(CRP)[SMD=-0.53,95%CI(-0.90,-0.16),P=0.005]。CRP和HDL、LDL、DBP呈正相关,相关系数分别为0.35、0.26和0.28;CRP与SBP呈负相关,相关系数为-0.31。由此可见,心血管疾病患者参与有氧运动能够在一定程度改善心脏功能、脂质代谢和炎症因子水平,并且心脏功能和脂质代谢、炎症之间存在相关性。To investigate the correlation between aerobic exercise and cardiac function,lipid metabolism,and inflammation in patients with cardiovascular disease,by searching PubMed,Embase,Scopus,and China National Knowledge Infrastructure(CNKI)databases for relevant studies on the effects of aerobic exercise on cardiac function,lipid metabolism,and inflammatory factors in patients with cardiovascular disease,Meta-analysis and correlation analysis were conducted using RevMan5.4 and R software.The results show that aerobic exercise significantly reduces B-type natriuretic peptide(BNP)[SMD=-0.84,95%CI(-1.34,-0.34),P=0.001],systolic blood pressure(SBP)[SMD=-0.55,95%CI(-0.86,-0.25),P=0.0004],and diastolic blood pressure(DBP)[SMD=-0.99,95%CI(-1.67,-0.32),P=0.004],LDL[SMD=-0.53,95%CI(-0.89,-0.18),P=0.003],and C-reactive protein(CRP)[SMD=-0.53,95%CI(-0.90,-0.16),P=0.005].CRP is positively correlated with HDL,LDL,and DBP,with correlation coefficients of 0.35,0.26,and 0.28,respectively.CRP is negatively correlated with SBP,with correlation coefficients of-0.31.From this,it can be seen that aerobic exercise can improve heart function,lipid metabolism,and levels of inflammatory factors to a certain extent in patients with cardiovascular diseases,and there is a correlation between heart function,lipid metabolism,and inflammation.

关 键 词：有氧运动 心血管疾病 心脏功能 脂质代谢 炎症 C-反应蛋白 关联性分析 

分 类 号：R195.4[医药卫生—卫生统计学]