核酸感受器DDX60在疾病中的作用研究进展  

Advances in the role of the nucleic acid receptor DDX60 in diseases

作　　者：席毓灵 隋丽娜 何良梅 刘志平 XI Yu-lin;SUI Li-na;HE Liang-mei;LIU Zhi-ping(School of Basic Medicine,Gannan Medical University;Department of Gastroenterology,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医科大学基础医学院 [2]赣南医科大学第一附属医院消化内科,江西赣州341000

出　　处：《赣南医科大学学报》2025年第2期117-123,共7页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(31960163,32260191);井冈学者科研启动金项目(QD202205);赣南医学院第一附属医院院级科技计划项目(YJZD202007);江西省自然科学基金青年项目(20224BAB216070);赣南医学院第一附属医院博士启动基金项目(QD202225)。

摘　　要：核酸感受器在先天性免疫、炎症和肿瘤中具有重要的调控作用。DEAD-box RNA解旋酶(DEAD-box helicase)是哺乳动物基因中最大的RNA解旋酶家族,除具有解旋酶功能外,部分解旋酶分子也具有核酸感受器功能,可以对内源性或外源性异常核酸物质做出反应。对核酸感受器的认识也从维持正常生理功能到病原防御再上升到参与疾病的发生发展。维甲酸诱导基因Ⅰ样受体(Retinoic acid inducible gene-Ⅰreceptors,RLRs)主要包括维甲酸诱导基因I(Retinoic acid inducible gene-Ⅰ,RIG-Ⅰ)和黑色素瘤分化相关基因5(Melanoma differentiationassociated gene 5,MDA5),是解旋酶家族中被鉴定为参与RNA配体识别的核酸感受器,它们在病原防御、炎症、肿瘤中的作用被广泛研究。DExD/H-box解旋酶60(DExD/H-box helicase 60,DDX60)是另一个被鉴定为功能区域类似RIG-Ⅰ样受体的解旋酶分子,近年来其在肿瘤、炎症、病原防御中的作用及机制也逐渐被揭示,本文就DDX60的相关研究进展进行总结分析。Nucleic acid receptors have important regulatory roles in innate immunity,inflammation and tumors.The nucleic acid deconjugating enzymes DEAD-box RNA family is the largest family of RNA helicases in mammalian genes.In addition to their deconjugating enzyme functions,some of the deconjugating enzyme molecules also function as nucleic acid receptors that respond to endogenous or exogenous aberrant nucleic acid substances.The understanding of nucleic acid-sensing receptors has also advanced from the maintenance of normal physiological functions to pathogenic defense and to involvement in disease development.Retinoic acid inducible gene-Ⅰ(RIG-Ⅰ)-like receptors,mainly including RIG-Ⅰand melanoma differentiation-associated gene 5(MDA5),are among the family of deconjugating enzymes identified as nucleic acid receptors involved in the recognition of RNA ligands,and their roles in pathogenic defense,inflammation,and tumors have been extensively investigated.DExD/H-box helicase 60(DDX60)is another molecule that has been identified as having functional regions similar to those of the deconjugating enzyme molecule of the RIG-Ⅰ-like receptor.In recent years,its role and mechanism in tumor,inflammation,and pathogenic defense have been gradually revealed.This paper summarizes and analyses the progress of the research related to DDX60.

关 键 词：DDX60 先天性免疫 病毒防御 炎症 肿瘤 

分 类 号：R392.1[医药卫生—免疫学]