司美格鲁肽注射液治疗2型糖尿病合并阻塞性睡眠呼吸暂停低通气综合征临床观察  

Clinical Observation of Semaglutide Injection in the Treatment of Type 2 Diabetes Mellitus Complicated with Obstructive Sleep Apnea-Hypopnea Syndrome

作　　者：周蓉敏 肖秘苏 赵贇[1] 成佩秋 张剑萍[1] 郭澄[1] ZHOU Rongmin;XIAO Misu;ZHAO Yun;CHENG Peiqiu;ZHANG Jianping;GUO Cheng(Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China 200233)

机构地区：[1]上海交通大学医学院附属第六人民医院,上海200233

出　　处：《中国药业》2025年第7期93-96,共4页China Pharmaceuticals

基　　金：国家自然科学基金面上项目[81873042];上海交通大学附属第六人民医院院级回顾性临床研究课题[沪六院内科字(2020)第1号];上海交通大学医学院青年科技创新工作室项目[沪交医团[2022]24号]。

摘　　要：目的探讨司美格鲁肽注射液对2型糖尿病(T2DM)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血糖、血脂、呼吸参数指标及体质量的影响。方法选取医院2022年4月至2023年7月收治的T2DM合并OSAHS患者112例,按降血糖方案的不同分为观察组(63例)和对照组(49例)。观察组患者予司美格鲁肽,对照组患者予常规降血糖方案,两组患者均连续治疗24周。结果治疗后,两组患者的空腹血糖、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1C)、总胆固醇(TC)、甘油三酯(TG)、体质量、呼吸暂停低通气指数(AHI)、白细胞介素6(IL-6)水平均显著降低(P<0.05),最低脉搏容积血氧饱和度(LSpO2)、空腹C肽(FC-P)均显著升高(P<0.05),且观察组患者的2 hPG,HbA1C,TC,TG,AHI,IL-6水平及体质量均显著低于对照组(P<0.05),FC-P显著高于对照组(P<0.05)。观察组和对照组患者的不良反应发生率相当(6.35%比2.04%,P>0.05)。结论司美格鲁肽治疗T2DM合并OSAHS的效果良好,可有效控制患者的血糖,改善血脂和缺氧情况,减轻睡眠呼吸暂停的严重程度,且安全性良好。Objective To investigate the effect of semaglutide injection on blood glucose,blood lipids,respiratory parameters,and body weight in patients with type 2 diabetes mellitus(T2DM)complicated with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods A total of 112 patients with T2DM complicated with OSAHS admitted to the hospital from April 2022 to July 2023 were selected and divided into the observation group(63 cases)and the control group(49 cases)based on different hypoglycemic regimens.The patients in the observation group received semaglutide therapy,while the patients in the control group received conventional hypoglycemic therapy.Both groups were treated continuously for 24 weeks.Results After treatment,the fasting blood glucose(FBG),2 h postprandial blood glucose(2 hPG),glycated hemoglobin(HbA1C),total cholesterol(TC),triglycerides(TG),body mass,apnea-hypopnea index(AHI),and interleukin-6(IL-6)levels in the two groups significantly decreased(P<0.05);the lowest pulse oxygen saturation(LSpO₂)and fasting C-peptide(FC-P)levels in the two groups significantly increased(P<0.05),and the levels of 2 hPG,HbA1C,TC,TG,AHI,IL-6,and body mass in the observation group were significantly lower than those in the control group(P<0.05),while the FC-P level in the observation group was significantly higher than that in the control group(P<0.05).The incidence of adverse reactions was comparable between the observation group and the control group(6.35%vs.2.04%,P>0.05).Conclusion Semaglutide in the treatment of T2DM complicated with OSAHS has good efficacy and safety,which can effectively control blood glucose,improve blood lipids and hypoxia,and reduce the severity of sleep apnea.

关 键 词：司美格鲁肽 2型糖尿病 阻塞性睡眠呼吸暂停低通气综合征 血糖 血脂 呼吸暂停低通气指数 

分 类 号：R969.4[医药卫生—药理学] R977.15[医药卫生—药学]