生肌玉红膏联合柑橘黄酮片对混合痔术后患者肛门功能、创面恢复及创面组织的影响  

Effect of Shengji Yuhong Cream Combined with Citrus Flavonoid Tablets on Anal Function,Wound Healing,and Wound Tissue in Postoperative Patients with Mixed Hemorrhoids

作　　者：杨周雨 钟培 李可 陈劲松 李心茹 YANG Zhouyu;ZHONG Pei;LI Ke;CHEN Jinsong;LI Xinru(Changsha Hospital of Traditional Chinese Medicine·Changsha Eighth Hospital,Changsha,Hunan,China 410100)

机构地区：[1]湖南省长沙市中医医院·湖南省长沙市第八医院,湖南长沙

出　　处：《中国药业》2025年第7期101-104,共4页China Pharmaceuticals

基　　金：湖南省中医药管理局中医药科研课题[B2023105]。

摘　　要：目的探讨生肌玉红膏联合柑橘黄酮片对混合痔术后患者肛门功能、创面恢复及创面组织纤维连接蛋白(FN)、血管内皮生长因子(VEGF)、CXC型趋化因子受体4(CXCR4)、Ⅰ型胶原蛋白(COL-Ⅰ)的影响。方法选取医院2022年1月至2023年12月收治的混合痔患者160例,按随机数字表法分为试验组和对照组,各80例,两组因治疗依从性差或自行退出研究各剔除1例,最终各纳入79例。两组患者均予混合痔外剥内扎术,术后予抗菌药物静脉滴注、浴舒洗液等常规治疗,对照组患者术后加用常规凡士林纱条和口服柑橘黄酮片治疗,试验组患者术后加用生肌玉红膏纱条和口服柑橘黄酮片治疗。两组患者均治疗至创面愈合。结果试验组患者的渗出物消失时间、肉芽组织与创面相平时间、创面愈合时间均显著短于对照组(P<0.05)。治疗后,两组患者的直肠最大容量阈值、肛管静息压、直肠感觉阈值均显著低于治疗前(P<0.05),但试验组均显著高于对照组(P<0.05),肛管收缩压与治疗前比较均无显著差异(P>0.05);两组患者的肛门疼痛、水肿评分均显著降低(P<0.05),且试验组均显著低于对照组(P<0.05);两组患者创面组织的VEGF,FN,COL-Ⅰ表达量均显著增加(P<0.05),CXCR4表达量均显著减少(P<0.05),且试验组均显著优于对照组(P<0.05)。试验组患者的并发症发生率为3.80%,显著低于对照组的12.66%(P<0.05)。结论生肌玉红膏联合柑橘黄酮片用于混合痔术后,可促进术后新生血管形成、创面愈合和肛门功能恢复,减少并发症。Objective To investigate the effect of Shengji Yuhong Cream combined with Citrus Flavonoid Tablets on anal function,wound healing,and the levels of wound tissue such as fibronectin(FN),vascular endothelial growth factor(VEGF),CXC chemokine receptor 4(CXCR4),and typeⅠcollagen(COL-Ⅰ)in postoperative patients with mixed hemorrhoids.Methods A total of 160 patients with mixed hemorrhoids admitted to the hospital from January 2022 to December 2023 were selected and divided into the test group and the control group by the random number table method,with 80 cases in each group.One case in each group was excluded due to poor treatment compliance or voluntary withdrawal,resulting in 79 cases in each group.The patients in the two groups underwent external excision and internal ligation for mixed hemorrhoids,and received routine treatments such as intravenous infusion of antibiotics and bath solution after surgery.The patients in the control group were treated with conventional Vaseline gauze strips and oral Citrus Flavonoids Tablets after surgery,while the patients in the test group were treated with Shengji Yuhong Cream gauze strips and oral Citrus Flavonoid Tablets after surgery.Both groups were treated until the wound healed.Results The disappearance time of exudate,the time for granulation tissue to level with the wound,and the time for wound healing in the test group were significantly shorter than those in the control group(P<0.05).After treatment,the maximum rectal volume threshold,anal resting pressure,and rectal sensory threshold in the two groups were significantly lower than those before treatment(P<0.05),but those in the test group were significantly higher than those in the control group(P<0.05);there was no significant difference in anal systolic pressure compared with those before treatment(P>0.05);the anal pain and edema scores in the two groups were significantly lower than those before treatment(P<0.05),and those in the test group were significantly lower than those in the control group(P<0.05);the exp

关 键 词：生肌玉红膏 柑橘黄酮片 混合痔 新生血管形成 创面愈合 肛门功能 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]