自拟柴黄利胆方联合消炎利胆胶囊治疗慢性胆囊炎临床研究  

Clinical Study of Self-Made Chaihuang Lidan Decoction Combined with Xiaoyan Lidan Capsules in the Treatment of Chronic Cholecystitis

作　　者：杨威涛 曹鹏飞 张志宏 杨娇 杨泽江 YANG Weitao;CAO Pengfei;ZHANG Zhihong;YANG Jiao;YANG Zejiang(Chengde Hospital of Traditional Chinese Medicine,Chengde,Hebei,China 067000;Hebei Yiling Hospital,Shijiazhuang,Hebei,China 050000)

机构地区：[1]河北省承德市中医院,河北承德067000 [2]河北以岭医院,河北石家庄050000

出　　处：《中国药业》2025年第7期109-112,共4页China Pharmaceuticals

基　　金：河北省中医药管理局科研计划项目[2021195]。

摘　　要：目的探讨自拟柴黄利胆方联合消炎利胆胶囊治疗慢性胆囊炎的临床疗效,以及对患者胆囊动脉血流动力学的影响。方法选取医院2021年9月至2023年9月收治的肝胆湿热型慢性胆囊炎患者106例,按随机数字表法分为对照组和观察组,各53例。对照组患者予消炎利胆胶囊,观察组患者在对照组治疗基础上加用自拟柴黄利胆方。两组均以30 d为1个疗程,共治疗3个疗程。结果观察组的总有效率为90.57%,显著高于对照组的75.47%(P<0.05)。治疗后,两组患者的胆囊动脉收缩期最大血流速度、舒张期最小血流速度、中医证候(胁肋疼痛、脘腹胀闷、口苦口干、舌红苔黄)积分、肝胆生化指标(总胆汁酸、总胆红素、天门冬氨酸氨基转移酶、丙氨酸氨基转移酶)、炎性因子(转化生长因子β1、B细胞活化因子受体、单核细胞趋化蛋白4)水平均显著低于治疗前(P<0.05),且观察组上述指标均显著低于对照组(P<0.05);搏动指数、阻力指数均显著高于治疗前(P<0.05),且观察组上述指标均显著高于对照组(P<0.05)。观察组与对照组不良反应发生率相当(11.32%比7.55%,P>0.05)。结论自拟柴黄利胆方联合消炎利胆胶囊治疗慢性胆囊炎的临床疗效良好,可减轻患者的主要中医证候,降低肝胆生化指标,改善胆囊动脉血流动力学状态,抑制炎性因子表达,且安全性良好。Objective To investigate the clinical efficacy of self-made Chaihuang Lidan Decoction combined with Xiaoyan Lidan Capsules in the treatment of chronic cholecystitis,and its effect on gallbladder artery hemodynamics.Methods A total of 106 patients with chronic cholecystitis(live-gallbladder dampeness-heat type)admitted to the hospital from September 2021 to September 2023 were selected and randomly divided into the control group and the observation group by the random number table method,with 53 cases in each group.The patients in the control group received Xiaoyan Lidan Capsules,while the patients in the observation group additionally received self-made Chaihuang Lidan Decoction.Both groups were treated for three courses with 30 d as a course.Results The total effective rate in the observation group was 90.57%,which was significantly higher than 75.47%in the control group(P<0.05).After treatment,the gallbladder artery peak systolic velocity(PSV),end-diastolic velocity(EDV),traditional Chinese medicine(TCM)syndrome scores(hypochondriac pain,abdominal distension and pain,bitter taste and dry mouth,red tongue with yellow coating),hepatobiliary biochemical indexes[total bile acid,total bilirubin,aspartate aminotransferase(AST),alanine aminotransferase(ALT)],and inflammatory factors[transforming growth factor-β1(TGF-β1),B-cell activating factor receptor(BAFF-R),monocyte chemoattractant protein-4(MCP-4)]in the two groups were significantly lower than those before treatment(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05);the pulsatility index(PI)and resistance index(RI)in the two groups were significantly higher than those before treatment(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions was comparable between the observation group and the control group(11.32%vs.7.55%,P>0.05).Conclusion Self-made Chaihuang Lidan Decoction combined with Xiaoyan Lidan Capsules in the

关 键 词：自拟柴黄利胆方 消炎利胆胶囊 慢性胆囊炎 胆囊动脉 血流动力学 临床疗效 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]