药学干预肠内营养乳剂(TPF-T)临床应用效果评价  

Effect Evaluation of Pharmaceutical Intervention in Clinical Application of Enteral Nutrition Emulsion(TPF-T)

作　　者：丁云霞 黄亮 梁茂本[1] DING Yunxia;HUANG Liang;LIANG Maoben(Huai′an First Hospital Affiliated to Nanjing Medical University,Huai′an,Jiangsu,China 223300)

机构地区：[1]南京医科大学附属淮安第一医院,江苏淮安223300

出　　处：《中国药业》2025年第7期121-125,共5页China Pharmaceuticals

摘　　要：目的为临床正确应用肠内营养乳剂(TPF-T)(以下简称TPF-T)提供参考。方法按是否有临床药师参与干预将医院重症医学病房、急诊科(包括抢救监护室)、胃肠外科、肿瘤放疗科等科室2024年1月至3月收治的163例患者的286份应用TPF-T的长期医嘱设为对照组,将2024年4月至6月收治的180例患者的262份应用TPF-T的长期医嘱设为干预组,比较两组患者存在TPF-T禁用或不适宜用药情况(严重肾功能不全、严重低氧血症、高碳酸血症或酸中毒等)的医嘱率。结果对照组和干预组患者的平均年龄分别为(68.87±14.27)岁、(69.16±12.67)岁,≥61岁老年患者分别有120例(73.62%)、140例(77.78%)。严重肾功能不全患者应用TPF-T的对照组有34份(11.89%)、干预组有14份(5.34%);禁用或不适宜用药情况两组占比均最高,干预组的占比为11.83%,显著低于对照组的26.22%(χ^(2)=18.153,P<0.001)。结论临床药师通过对TPF-T长期医嘱的持续性干预,可规范其临床合理使用,提高用药安全,但仍需进一步改进。Objective To provide a reference for the rational clinical use of enteral nutrition emulsion(TPF-T).Methods A total of 286 long-term medical orders for TPF-T from 163 patients(without clinical pharmacists'intervention)admitted to intensive care units,emergency departments(including resuscitation wards),gastrointestinal surgery,and oncology radiotherapy departments from January to March 2024 were selected as the control group,while 262 long-term medical orders for TPF-T from 180 patients(with pharmacists'intervention)admitted to those departments from April to June 2024 were selected as the intervention group.The rates of TPF-T orders with contraindications or inappropriate usage(severe renal insufficiency,severe hypoxemia,hypercapnia,or acidosis)were compared between the two groups.Results The mean ages of patients in the control group and intervention group were(68.87±14.27)years old and(69.16±12.67)years old,respectively,with 120 cases(73.62%)and 140 cases(77.78%)aged≥61 years.There were 34 orders(11.89%)in the control group and 14 orders(5.34%)involved TPF-T use in patients with severe renal insufficiency in the control group and the intervention group,respectively.The rate of contraindications or inappropriate usage was highest in the two groups,with 11.83%in the intervention group,which was significantly lower than 26.22%in the control group(χ^(2)=18.153,P<0.001).Conclusion Continuous pharmaceutical intervention by clinical pharmacists in the long-term medication orders for TPF-T can standardize clinical rational use and improve medication safety.However,further improvements are still required.

关 键 词：药学干预 肠内营养乳剂(TPF-T) 效果评价 

分 类 号：R95[医药卫生—药学] R978.1