1例左氧氟沙星联合万古霉素致急性泛发性发疹性脓疱病的药学监护  

Pharmaceutical Care of a Case of Acute Generalized Exanthematous Pustulosis Caused by Levofloxacin Combined with Vancomycin

作　　者：张文 张萍 崔建蓉[1] ZHANG Wen;ZHANG Ping;CUI Jianrong(Chengdu Seventh People′s Hospital,Chengdu,Sichuan,China 610200)

机构地区：[1]四川省成都市第七人民医院,四川成都610200

出　　处：《中国药业》2025年第7期125-128,I0001,共5页China Pharmaceuticals

基　　金：四川省成都市卫生健康委员会医学科研课题[2023573]

摘　　要：目的探讨临床药师在急性泛发性发疹性脓疱病(AGEP)伴重症感染患者临床诊疗中的作用。方法临床药师通过参与1例左氧氟沙星联合万古霉素致AGEP患者的临床诊疗过程,充分运用药学专业知识,结合相关诊疗指南及文献,对广泛耐药肺炎克伯菌(XDR-KP)感染的可能性进行评估,调整药物治疗方案,及时甄别药品不良反应,进行药学监护。结果停用致敏药物,对症处理后,患者感染指标趋于正常,皮疹消退,患者预后良好。结论临床药师参与临床诊疗,可从药学角度发挥优势,提升患者治疗的安全性和有效性。Objective To investigate the role of the clinical pharmacist in the clinical diagnosis and treatment of severe sepsis patient with acute generalized exanthematous pustulosis(AGEP).Methods The clinical pharmacist participated in the clinical diagnosis and treatment of a patient with AGEP caused by levofloxacin combined with vancomycin,made full use of pharmaceutical knowledge and relevant diagnosis and treatment guidelines and literature to evaluate the possibility of extensively drug-resistant Klebsiella pneumoniae(XDR-KP)infection,adjuste drug treatment plans,timely identify adverse drug reactions,and provide pharmaceutical care.Results After disabled allergenic drugs and given symptomatic treatment,the patient's infection indicators tended to be normal,the rash subsided.Finally,the patient's prognosis was good.Conclusion Clinical pharmacists participating in clinical diagnosis and treatment can give full play to their advantages from the perspective of pharmacy,improve the safety and efficacy of the treatment.

关 键 词：左氧氟沙星 万古霉素 急性泛发性发疹性脓疱病 药学监护 

分 类 号：R95[医药卫生—药学] R978.1