Artificial hearing systems based on functional cochlea models  

作　　者：Jinke Chang Sita Tarini Clark Iwan Roberts Filip Hrncirik Zhipeng Zhang Manohar Bance 

机构地区：[1]Department of Engineering Science,University of Oxford,Parks Road,Oxford OX13PJ,United Kingdom [2]Division of Surgery&Interventional Science,University College London,London NW32PF,United Kingdom [3]Department of Clinical Neurosciences,University of Cambridge,Cambridge CB20QQ,United Kingdom [4]Cambridge Hearing Group,Cambridge,United Kingdom [5]Nuffield Department of Medicine,University of Oxford,Oxford,United Kingdom

出　　处：《International Journal of Extreme Manufacturing》2025年第1期73-94,共22页极端制造(英文)

基　　金：support from the UCL GRS/ORS scholarship;UCL Fellowship Incubator Award;supported by the NIHR Cambridge Biomedical Research Centre(NIHR203312);funded by the Royal National Institute for Deaf People(RNID,G100138);funded by the Rosetrees Trust Enterprise Fellowship(EF2020100099);RNID Flexigrant(F112);Wellcome Trust Developing Concept Fund(RG93172/BANCE/40181);by the Evelyn Trust;funded by the Woolf Fisher Trust,New Zealand;the Cambridge Commonwealth,European,&International Trust;by Trinity College;University of Cambridge。

摘　　要：The cochlea is one of the most complex organs in the human body,exhibiting a complex interplay of characteristics in acoustic,mechanical,electrical,and biological functions.Functional cochlea models are an essential platform for studying hearing mechanics and are crucial for developing next-generation auditory prostheses and artificial hearing systems for sensorineural hearing restoration.Recent advances in additive manufacturing,organ-on-a-chip models,drug delivery platforms,and artificial intelligence have provided valuable insights into how to manufacture artificial cochlea models that more accurately replicate the complex anatomy and physiology of the inner ear.This paper reviews recent advancements in the applications of advanced manufacturing techniques in reproducing the physical,biological,and intelligent functions of the cochlea.It also outlines the current challenges to developing mechanically,electrically,and anatomically accurate functional models of the inner ear.Finally,this review identifies the major requirements and outlook for impactful research in this field going forward.Through interdisciplinary collaboration and innovation,these functional cochlea models are poised to drive significant advancements in hearing treatments,and ultimately enhance the quality of life for individuals with hearing loss.

关 键 词：functional cochlea model auditory system hearing loss advanced manufacturing artificial hearing 

分 类 号：R76[医药卫生—耳鼻咽喉科]