中国妊娠期妇女戊型肝炎病毒IgG抗体阳性率meta分析  

Positive rates of hepatitis E virus IgG antibodies in pregnant women in China:a meta-analysis

作　　者：谢启新 叶春梅 卢肇骏 顾雯雯[1] 王婧[1] 杜渐[1] 杨瑛莹 刘艳[1] XIE Qixin;YE Chunmei;LU Zhaojun;GU Wenwen;WANG Jing;DU Jian;YANG Yingying;LIU Yan(Hangzhou Center for Disease Control and Prevention(Hangzhou Health Supervision Institution),Hangzhou 310000,China;Hangzhou Linping District Center for Disease Control and Prevention(Hangzhou Linping District Health Supervision Institution),Hangzhou 311222,China)

机构地区：[1]杭州市疾病预防控制中心(杭州市卫生监督所),杭州310000 [2]杭州市临平区疾病预防控制中心(杭州市临平区卫生监督所),杭州311222

出　　处：《中国公共卫生》2025年第2期234-238,共5页Chinese Journal of Public Health

摘　　要：目的了解中国妊娠期妇女戊型肝炎病毒(HEV)免疫球蛋白G(IgG)抗体的阳性率,为我国妊娠期妇女戊型肝炎的预防控制提供参考依据。方法检索Pubmed、Web of Science、中国知网和万方资源数据库,并辅以文献追溯法收集1989年1月1日—2023年12月31日国内外公开发表的中国妊娠期妇女HEV血清流行率调查的相关文献;应用R 3.5.2软件对纳入的文献进行meta分析。结果最终纳入15篇文献(中文文献8篇、英文文献7篇),累计研究对象36188人;meta分析结果显示,中国妊娠期妇女HEV IgG抗体阳性率为13%(95%CI=11%~16%);亚组分析结果显示,年龄<30岁和≥30岁妊娠期妇女的HEV IgG抗体阳性率分别为18%(95%CI=12%~24%)和15%(95%CI=10%~19%),居住在城市和农村地区妊娠期妇女的HEV IgG抗体阳性率分别为29%(95%CI=3%~55%)和25%(95%CI=5%~45%),孕早期、孕中期和孕晚期妊娠期妇女的HEV IgG抗体阳性率分别为16%(95%CI=3%~28%)、13%(95%CI=7%~18%)和15%(95%CI=10%~21%),不同年龄、居住地和孕期妊娠期妇女HEV IgG抗体阳性率差异均无统计学意义(均P>0.05);敏感性分析和发表偏倚检验结果显示,本次meta分析纳入的文献不存在发表偏倚,结果较为稳定。结论中国妊娠期妇女HEV IgG抗体阳性率较高,应重点关注妊娠期妇女这一高危人群,做好HEV感染的防控工作。Objective To investigate the positive rate of hepatitis E virus(HEV)immunoglobulin G(IgG)antibodies in pregnant women in China and to provide a reference for the prevention and control of hepatitis E in the women.Methods PubMed,Web of Science,China National Knowledge Infrastructure(CNKI),and Wanfang Data were searched,supplemented by a retrospective literature search,to collect relevant literature published domestically and internationally from January 1,1989,to December 31,2023,on the seroprevalence of HEV in pregnant women in China.R 3.5.2 software was used for meta-analysis of the included literature.Results A total of 15 articles(8 in Chinese and 7in English)were included,with a cumulative study population of 36188.The meta-analysis showed that the positive rate of HEV IgG antibodies among pregnant women in China was 13%(95%confidence interval[95%CI]:11%–16%).Subgroup analysis showed that the positive rates of HEV IgG antibodies in pregnant women younger than 30 years old and 30 years old and older were 18%(95%CI:12%–24%)and 15%(95%CI:10%–19%),respectively;the positive rates of HEV IgG antibodies in pregnant women living in urban and rural areas were 29%(95%CI:3%–55%)and 25%(95%CI:5%–45%),respectively;and the positive rates of HEV IgG antibodies in pregnant women in the first,second,and third trimesters were 16%(95%CI:3%–28%),13%(95%CI:7%–18%),and 15%(95%CI:10%–21%),respectively.There were no statistically significant differences in the positive rates of HEV IgG antibodies among pregnant women of different ages,residences,and gestational ages(all P>0.05).Sensitivity analysis and publication bias tests showed that there was no publication bias in the literature included in this meta-analysis,and the results were relatively stable.Conclusions The positive rate of HEV IgG antibodies among pregnant women in China is relatively high.Attention should be paid to this high-risk group,and prevention and control measures for HEV infection should be strengthened.

关 键 词：戊型肝炎病毒(HEV) 免疫球蛋白G(IgG)抗体 阳性率 妊娠期妇女 中国 META分析 

分 类 号：R71[医药卫生—妇产科学]