丹系大白猪与亚洲野猪全基因组选择信号分析  

Analysis of genome-wide selection signatures in Danish Large White pig and Asian Sus scrofa

作　　者：吴旭东 刘孟全 李默 张威 吴涛[1] 赵子龙 殷宗俊[3] WU Xudong;LIU Mengquan;LI Mo;ZHANG Wei;WU Tao;ZHAO Zilong;YIN Zongjun(Institute of Animal Husbandry and Veterinary Medicine,Anhui Academy of Agricultural Sciences/Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering,Hefei 230001,China;Anhui Da Zi Ran Pig Breeding Farm Corporation Limited,Huaibei 235100,China;College of Animal Science and Technology,Anhui Agricultural University,Hefei 230031,China)

机构地区：[1]安徽省农业科学院畜牧兽医研究所/畜禽产品安全工程安徽省重点实验室,安徽合肥230001 [2]安徽大自然种猪股份有限公司,安徽淮北235100 [3]安徽农业大学动物科技学院,安徽合肥230031

出　　处：《畜牧与兽医》2025年第4期14-19,共6页Animal Husbandry & Veterinary Medicine

基　　金：安徽省科技重大专项项目(202203a06020031);安徽省瘦肉型种猪选育与种质创新联合攻关项目。

摘　　要：旨在分析丹系大白猪与亚洲野猪基因组选择清除差异。本研究利用全基因组重测序技术获得43头丹系大白猪及6头亚洲野猪遗传变异信息,联合群体分化程度(Fst)及多样性的变化倍数(π值)两种方法检测受选择区域,并对区域内所含基因进行功能富集分析。结果:丹系大白猪相对于亚洲野猪共有134个受选择区域,包含103个基因,基因本体(GO)功能富集条目主要参与酶代谢,京都基因与基因组百科全书(KEGG)功能富集通路则与生长及生殖相关;经过筛选,发现APC2、AQP9、KISS1R、PAPPA2、PTBP1这5个与大白猪繁殖性能相关的候选基因受到强烈的正向选择。本研究结果进一步揭示了丹系大白猪高繁殖力特性的遗传基础,为国外良种的本土化选育及相关经济性状的分子标记位点开发提供参考。The aim of this study was to analyze the differences in genomic selection sweeps between Danish Large White(LW)and Asian Sus scrofa(SS)pigs.We obtained genetic variation information from 43 LW and 6 SS pigs using the whole-genome resequencing technology.Selection regions were detected using both Fst andπratio methods,and functional enrichment analysis was performed on the genes within these regions.The results showed that there were 134 selection regions in the LW pigs compared with the SS ones;these regions contained 103 genes.The GO functional enrichment terms were mainly involved in enzyme metabolism,while the KEGG functional pathways were asso⁃ciated with growth and reproduction.After screening,five candidate genes related to the reproductive performance of the Landrace pigs,namely APC2,AQP9,KISS1R,PAPPA2,and PTBP1,were found to be under strong positive selection.The results of this study further elucidated the genetic basis of the high reproductive performance of LW pigs and provided references for the domestication and selection of foreign breeds and the development of molecular markers for related economic traits.

关 键 词：丹系大白猪 亚洲野猪 全基因组重测序 选择清除 候选基因 

分 类 号：S828[农业科学—畜牧学]