阿司匹林对比格犬消化系统的毒性作用研究  

Damaging effects of aspirin on the canine digestive system

作　　者：刘京 陈勤勤 刘国芳[1] 林家琪 郝盼 LIU Jing;CHEN Qinqin;LIU Guofang;LIN Jiaqi;HAO Pan(Jiangsu Agriculture and Forestry Vocational Technical College,Jurong 212400,China;Shanghai Xinyuan Animal Medicine Co.,Ltd.,Shanghai 201700,China)

机构地区：[1]江苏农林职业技术学院,江苏句容212400 [2]上海信元动物药品有限公司,上海201700

出　　处：《畜牧与兽医》2025年第4期130-138,共9页Animal Husbandry & Veterinary Medicine

基　　金：江苏农林职业技术学院科技项目(2020kj027)。

摘　　要：为研究阿司匹林对犬消化系统的损伤作用,选取18只健康比格犬,年龄2岁,随机均分成3组,即Asp0组、Asp10组和Asp25组,分别给予每千克体重0、10、25 mg阿司匹林进行饲喂,每天2次,连续给药21 d。结果:与Asp0组相比,Asp25组试验犬自第1天起粪便呈潜血阳性,且间歇出现强阳性;自第4天起内窥镜检查评分显著增加(P<0.05);第1周体重和凝血机能显著下降(P<0.05),血清中免疫相关指标白细胞介素-2(IL-2)含量和血清溶菌酶(LZM)活性显著下降(P<0.05),肠道黏膜分泌型免疫球蛋白A(sIgA)含量也显著下降(P<0.05);第2周采食量和粪便性状评分显著下降(P<0.05);试验最后,胃黏膜层结构消失,黏膜肌层受损,黏膜下层水肿,结缔组织排列结构紊乱,且肠道黏膜sIgA含量显著下降(P<0.05)。Asp10组试验犬在试验周期内采食量和体重无明显变化;第3周,粪便性状评分和凝血机能显著高于Asp25组(P<0.05),潜血评分和血清免疫相关指标(IL-2、LZM和sIgA)显著低于Asp25组(P<0.05),病理组织学显示胃上皮虽有受损,但黏膜肌层结构完整。综上,犬口服25 mg/kg阿司匹林,持续给药21 d,可引起试验犬采食量和体重下降,胃黏膜糜烂出血,出现稀软血便,机体凝血机能下降,血清中细胞因子和黏膜免疫蛋白也随之变化,最终导致消化系统结构和功能损伤。To study the damaging effects of aspirin on the canine digestive system,18 healthy dogs were selected,randomly and equally di⁃vided into three groups which were given 0,10 and 25 mg/kg aspirin in the diet,i.e.the Asp0,Asp10 and Asp25 groups,twice daily for 21 consecutive days.The results showed that,compared with the Asp0 group,the faecal occult blood of the dogs in the Asp25 group became positive from day 1 and got strongly positive intermittently.The endoscopy scores for the dogs were significantly increased from day 4(P<0.05);and their body weight and coagulation function were significantly decreased in the first week(P<0.05),as were the serum levels of the immune-related indices interleukin-2(IL-2)and serum lysozyme activity(LZM)(P<0.05).The content of secretory immunoglobulin A(sIgA)in the intestinal mucosa of the dogs also decreased significantly(P<0.05).At the end of the experiment,the structure of the gas⁃tric mucosal layer in them disappeared,their mucosal muscularis propria was damaged,their submucosal layer was edematous,the arrange⁃ment of the connective tissues was disorganized,and the content of sIgA in their intestinal mucosa was significantly decreased(P<0.05).In the Asp10 group,there was no significant change in feed intake and body weight during the test.In the third week,the faecal character as⁃sessment and coagulation function of the group were higher than those of the Asp25 group,and their occult blood score and serum immunerelated indexes(IL-2,LZM,and sIgA)were lower than those of the Asp25 group.The pathological histology showed that the gastric epithe⁃lium of the Asp10 group was damaged,but their muscularis mucosa was structurally intact.The above results indicated that oral administra⁃tion of 25 mg/kg aspirin to dogs for 21 days caused a decrease in food intake and body weight,gastric mucosal erosion and bleeding,appear⁃ance of thin and soft bloody stools,a decrease in the bodys coagulation function and consequent changes in serum cytokines and mucosal im⁃mune proteins,whi

关 键 词：阿司匹林 犬 消化系统 损伤作用 

分 类 号：S859[农业科学—临床兽医学]