产气荚膜梭菌疫苗研究进展  

Advances inresearch on Clostridium perfringens vaccine

作　　者：曾梦 吴群 韩建成[1] 杨远廷 周汉林[1] ZENG Meng;WU Qun;HAN Jiancheng;YANG Yuanting;ZHOU Hanlin(Zhanjiang Experimental Station,Chinese Academy of Tropical Agricultural Sciences,Zhanjiang 524013,China)

机构地区：[1]中国热带农业科学院湛江实验站,广东湛江524013

出　　处：《畜牧与兽医》2025年第4期139-145,共7页Animal Husbandry & Veterinary Medicine

基　　金：中央级公益性科研院所基本科研业务费专项(1630102024005)。

摘　　要：产气荚膜梭菌(Clostridium perfringens)是一种在自然界及动物胃肠道内广泛存在的条件性致病菌,对畜禽养殖造成严重的经济损失。目前,接种疫苗是防控产气荚膜梭菌感染的主要手段,并有助于减少抗菌药物在畜禽养殖中的使用,减缓细菌耐药性的发展。本文综述了产气荚膜梭菌α、β、ε毒素蛋白作为疫苗抗原成分的应用,重点阐述在灭活疫苗、类毒素疫苗、基因工程活疫苗、纳米颗粒疫苗或佐剂和多表位疫苗5个方面的研究进展,以期为新型疫苗的研制提供参考。Clostridium perfringensis a conditionally pathogenic bacterium that is widely present in nature and in the gastrointestinal tract of animals,causing serious economic losses to livestock and poultry breeding.Vaccination is currently the mainstay of prevention and control of C.perfringens and has helped to reduce the use of antimicrobials in livestock farming and to slow down the development of bacterial resist⁃ance.This paper reviews the application of C.perfringensα,β,andεtoxin proteins as antigenic components of vaccines,and summarizes the research progress in four aspects,namely,toxoid vaccine,bacterial carrier vaccine,nanoparticle vaccine or adjuvant,and multi-epitope vaccine,with a view to providing reference for the development of novel vaccines.

关 键 词：产气荚膜梭菌 疫苗 抗原 毒素蛋白 

分 类 号：S855.3[农业科学—临床兽医学]