基于细菌纤维素的抗菌生物缝线的制备及性能研究  

Preparation and properties of antibacterial bio-suture based on bacterial cellulose

作　　者：刘秀童 姚春丽[1] 陈阁谷 LIU Xiutong;YAO Chunli;CHEN Gegu(School of Materials Science and Technology,Beijing Forestry University,Beijing,China)

机构地区：[1]北京林业大学材料学院,北京

出　　处：《东华大学学报(自然科学版)》2025年第1期80-88,共9页Journal of Donghua University(Natural Science)

基　　金：国家自然科学基金(22208023);北京市科技新星计划资助(Z211100002121099,20220484214);林业工程与森林培育学科创新引智基地2.0项目(BP0820033)。

摘　　要：细菌纤维素(BC)因其具有高结晶度、优异的亲水性和生物相容性,在生物医用领域如组织工程、伤口敷料及药物递送等方面展现出潜在应用价值。针对纯BC缝线柔韧性差及缺乏抗菌性的问题,以细菌纤维素凝胶膜为基底,利用2,3-环氧丙基三甲基氯化铵(EPTMAC)对BC进行阳离子季铵化改性处理,此举不仅降低了纯BC的结晶度,还赋予BC缝线良好的抗菌性,制备出具有阳离子性的BC凝胶膜。通过预拉伸—加捻—干燥三步法制备柔韧抗菌的阳离子细菌纤维素(CBC)缝线。研究结果表明,该缝线不仅力学性能得到显著提升(打结抗张强度为(21.5±1.1)N),还保持了良好的生物相容性,细胞存活率高达92.0%,并展现出99.9%的高效抗金黄葡萄球菌能力。与石油基缝合线相比,这种BC基生物缝线成本更低,且性能优异,能有效减少缝合处的二次伤害风险,在外科缝线领域具备巨大的应用前景和发展潜力。Bacterial cellulose(BC)possesses high crystallinity,excellent hydrophilicity and biocompatibility,holding potential applications in biomedical fields such as tissue engineering,wound dressings,and drug delivery.To address the issues of poor flexibility and lack of antibacterial properties in pure BC sutures,this study utilized bacterial cellulose gel film as a substrate and employed 2,3-epoxypropyl trimethyl ammonium chloride(EPTMAC)for cationic quaternization modification of BC.This modification not only reduced the crystallinity of pure BC but also endowed BC sutures with good antibacterial properties,resulting in the preparation of cationic BC gel films.Subsequently,a flexible and antibacterial cationic bacterial cellulose(CBC)suture was prepared through a three-step process of pre-stretching,twisting,and drying.The research findings demonstrate that the suture exhibits enhanced mechanical properties(knot tensile strength of(21.5±1.1)N),along with excellent biocompatibility and antibacterial performance,with a cell survival rate of up to 92.0%and antibacterial efficiency of 99.9%.Compared to petroleum-based sutures,this BC-based biodegradable suture offers low cost and superior performance,effectively addressing secondary injury issues at the suture site,and holds tremendous potential for applications in the field of surgical sutures.

关 键 词：细菌纤维素 缝线 抗菌 生物相容性 季铵化改性 

分 类 号：TQ[化学工程]