循证医学驱动临床前动物实验成果的转化与利用  

Evidence-based medicine driving the translation and application of preclinical animal experiment results

作　　者：易少威 张俊华[4,5] 马彬 YI Shaowei;ZHANG Junhua;MA Bin(Center for Evidence-Based Medicine,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China;Research Center for Medical Device Regulatory Science,Lanzhou University,Lanzhou 730000,China;Industry Center for Evidence-Based Research and Evaluation Standards in Medical Devices,Gansu Province,Lanzhou 730000,China;Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Haihe Modern Chinese Medicine Laboratory,Tianjin 301617,China)

机构地区：[1]兰州大学基础医学院循证医学中心,甘肃兰州730000 [2]兰州大学医疗器械监管研究中心,甘肃兰州730000 [3]甘肃省医疗器械循证研究与评价标准行业中心,甘肃兰州730000 [4]天津中医药大学中医药研究院,天津301617 [5]现代中医药海河实验室,天津301617

出　　处：《兰州大学学报(医学版)》2025年第2期1-9,共9页Journal of Lanzhou University(Medical Sciences)

基　　金：甘肃省自然科学基金资助项目(5JRRA046);兰州市科技计划资助项目(2022-3-8)。

摘　　要：临床前动物实验作为基础医学成果向临床转化的重要桥梁,长期面临结果可重复性差和转化率低的挑战。循证医学通过基于证据的持续积累,并通过科学验证与应用,为解决临床前动物实验面临的挑战提供了新思路、新工具、新方法、新途径和新证据。基于目前临床前动物实验在转化应用过程中存在的局限性和不足、发展机遇与挑战,结合循证医学未来的发展趋势,本研究详细介绍如何借鉴循证医学方法理论,提升临床前动物实验成果的科学性与可靠性,探讨其在临床前动物实验成果转化中面临的发展机遇与挑战。Preclinical animal experiments,as a bridge for translating basic medical research into clinical applications,had long faced challenges such as poor reproducibility and low translation rates.Evidence-based medicine,through the continuous accumulation of evidence and its scientific validation and application has provided new perspectives,tools,methods,approaches,and evidence to address these challenges in preclinical animal experiments.Based on the limitations and challenges that existed in the translational application of preclinical animal experiments,as well as the opportunities for development,this study systematically analyzed how the theoretical framework of evidence-based medicine had been applied to enhance the scientific rigor and reliability of preclinical animal experiment outcomes.Furthermore,it explored the opportunities and challenges that had arisen in the translation of preclinical animal experiment findings,considering the trends in the development of evidence-based medicine.

关 键 词：循证医学 动物实验 基础医学 成果转化 实验动物 临床前研究 

分 类 号：R332[医药卫生—人体生理学]