Classic Chinese herbal formula Guizhi-Fuling Wan:a complementary treatment for polycystic ovary syndrome  

作　　者：Nan Yang Ri-Liang Su Ning Zhang Ping Han Tian-Jun Liu Wen-Qi Ge Ke Ma Mei-Lin Du Xiu-Yang Li 

机构地区：[1]School of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China [2]Department of Reproductive Medicine,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250021,China [3]Department of Traditional Chinese Medicine,Wucheng County People’s Hospital,Dezhou 253399,China [4]Cheung Kong College of Art and Design,Shantou University,Shantou 515063,China

出　　处：《Integrative Medicine Discovery》2025年第8期1-14,共14页

基　　金：supported by funds from the Natural Science Foundation of Shandong Province(No.ZR2020MH346;No.ZR2021MH003);the National Natural Science Foundation of China(No.81273667).

摘　　要：Polycystic ovary syndrome(PCOS)is a prevalent endocrine disorder that poses a significant threat to women’s health.As a classical traditional Chinese medicine(TCM)formulation,Guizhi-Fuling Wan(GFW)has a good application prospect in the complementary treatment of PCOS.This study aimed to systematically summarize the traditional efficacy and pharmacological composition of the Chinese medicines contained in GFW and evaluate the clinical efficacy and safety of their active ingredients in the complementary treatment of PCOS.A growing number of studies have demonstrated that GFW is effective at complementally treating PCOS through various mechanisms,including inhibiting inflammatory responses,modulating the intraovarian extracellular matrix,regulating apoptosis and autophagy in granulosa cells,and correcting oxidative stress imbalances.In addition,the GFW has been shown to be effective in treating the complications of PCOS.However,there are several problems,and future work should focus on elucidating the efficacy,safe dosage,and safety of different dosage forms of GFW,increasing the toxicological value of traditional Chinese medicine,and confirming the safety of the combination of GFW with Western medicine for the treatment of PCOS.

关 键 词：Guizhi-Fuling Wan polycystic ovary syndrome clinical application therapeutic mechanisms safety evaluation 

分 类 号：R71[医药卫生—妇产科学]