基于信号放大策略的生物传感器检测黄曲霉毒素M_(1)研究进展  

Research progress on detection of aflatoxin M_(1) by biosensors based on signal amplification strategy

作　　者：运欢 张宇昊[1,2,3] 马良 郭婷[1,2] YUN Huan;ZHANG Yuhao;MA Liang;GUO Ting(College of Food Science,Southwest University,Chongqing 400715,China;Chongqing Key Laboratory of Specialty Food Co-Built by Sichuan and Chongqing,Chongqing 400715,China;Key Laboratory of Condiment Supervision Technology for State Market Regulation,Chongqing 400715,China)

机构地区：[1]西南大学食品科学学院,重庆400715 [2]川渝共建特色食品重庆市重点实验室,重庆400715 [3]国家市场监管重点实验室(调味品监管技术),重庆400715

出　　处：《食品与发酵工业》2025年第7期387-395,共9页Food and Fermentation Industries

基　　金：重庆市技术创新与应用发展专项重点项目(CSTB2023TIAD-KPX0066,CSTB2024TIAD-KPX0106);国家自然科学基金联合基金项目(U22A20551);中央高校基本科研业务费专项资金资助项目(SWU-XJPY202310)。

摘　　要：黄曲霉毒素M_(1)是黄曲霉毒素B1在哺乳动物肝脏内转化而来的羟基化代谢产物,具有致癌性、免疫毒性、遗传毒性和致突变性。它在乳及乳制品中难以消除,对消费者的安全造成极大威胁。因此,开发快速灵敏的现场检测技术具有重要意义。生物传感器因其便携、灵敏、智能化等优势广泛应用于真菌毒素检测中。该文综述了近年来基于信号放大策略构建的黄曲霉毒素M_(1)生物传感器的研究进展,探讨了信号放大策略在生物传感器应用中的优势及局限,并对信号放大策略的发展趋势进行展望。Aflatoxin M_(1) is a hydroxylated metabolite derived from aflatoxin B 1 in mammalian livers,exhibiting carcinogenic,immunotoxic,genotoxic,and mutagenic properties.It poses a significant threat to consumer safety as it is challenging to eliminate from milk and dairy products.Therefore,the development of rapid and sensitive on-site detection technologies is of paramount importance.Biosensors are widely used for the detection of mycotoxins,because of their advantages of portability,sensitivity,and intelligence.This article reviewed the research progress of aflatoxin M_(1) biosensor based on signal amplification strategy in recent years,discussing the advantages and limitations of signal amplification strategy in biosensor applications.This review also provided an outlook on the development trend of signal amplification strategy.

关 键 词：黄曲霉毒素M_(1) 生物传感器 信号放大策略 检测 

分 类 号：TP2[自动化与计算机技术—检测技术与自动化装置]