mtNET-mineral complex:a building block of calculus  

线粒体来源的中性粒细胞胞外陷阱介导肾结石形成的机制研究

作　　者：Meichen Wan Yina Zhu Dongxiao Hao Qianqian Wan Wen Niu Zhaoyang Ren Kehui Xu Weijun Qin Shiren Sun Wei Yi Kai Jiao Franklin Tay Lina Niu 伏雨桐;万美辰;朱轶娜;郝东晓;万千千;牛雯;任朝阳;许克惠;秦卫军;孙世仁;易蔚;焦凯;Franklin Tay;牛丽娜

机构地区：[1]State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Key Laboratory of Stomatology,Department of Prosthodontics,School of Stomatology,The Fourth Military Medical University,Xi’an 710032,China [2]Xijing Hospital,The Fourth Military Medical University,Xi’an 710032,China [3]Department of Stomatology,Tangdu Hospital,The Fourth Military Medical University,Xi’an 710038,China [4]The Dental College of Georgia,Augusta University,Augusta,30912,USA

出　　处：《Science Bulletin》2025年第5期652-656,共5页科学通报(英文版)

基　　金：National Natural Science Foundation of China(82325012);Shaanxi Key Scientific and Technological Innovation Team(2020TD-033).

摘　　要：Pathological mineralization,which encompasses conditions such as calculus,atherosclerotic calcified plaques,and heterotopic ossification in cartilage,leads to severe complications and has emerged as a significant medical issue[1].Calculus refers to stones or calculi that form within the body,typically in organs such as the kidneys,bladder,or gallbladder[2].The cost of managing kidney stones is expected to increase to$1.24 billion per year by 2030[3].Since these strategies aim at removing the already formed stones rather than addressing the root causes,the recurrence and retreatment rate of kidney stones is quite high.The most common type of kidney stones,namely calcium oxalate kidney stones,are essentially the ectopic mineralization in the urinary system[4].However,the exact mechanisms that cause this form of ectopic mineralization are not fully understood.Hence,investigating the process of ectopic mineralization in kidney stone formation is a worthy and important endeavor.

关 键 词：BLADDER ORGANS removing 

分 类 号：R69[医药卫生—泌尿科学]