Early-life exposure to gestational diabetes mellitus predisposes offspring to pediatric nonalcoholic fatty liver disease  

作　　者：Qian-Ren Zhang Yan Dong Jian-Gao Fan 

机构地区：[1]Center for Fatty Liver,Department of Gastroenterology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China [2]Department of Endocrinology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China [3]Shanghai Institute for Pediatric Research,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China [4]Shanghai Key Lab of Pediatric Gastroenterology and Nutrition,Shanghai 200092,China

出　　处：《Hepatobiliary & Pancreatic Diseases International》2025年第2期128-137,共10页国际肝胆胰疾病杂志(英文版)

基　　金：supported by grants from the National Nat-ural Science Foundation of China(82170593);National Key R&D Program of China(2021YFC2700802);Collaborative Innovation Program of Shanghai Municipal Health Commission(2020CXJQ01)。

摘　　要：Nonalcoholic fatty liver disease(NAFLD)has emerged as the prevailing chronic liver disease in the pediatric population due to the global obesity pandemic.Evidence shows that prenatal and postnatal exposure to maternal abnormalities leads to a higher risk of pediatric NAFLD through persistent alterations in developmental programming.Gestational diabetes mellitus(GDM)is a hyperglycemic syndrome which has become the most prevalent complication in pregnant women.An increasing number of both epidemiologic investigations and animal model studies have validated adverse and long-term outcomes in offspring following GDM exposure in utero.Similarly,GDM is considered a crucial risk factor for pediatric NAFLD.This review aimed to summarize currently published studies concerning the inductive roles of GDM in offspring NAFLD de velopment during childhood and adolescence.Dysregulations in hepatic lipid metabolism and gut microbiota in offspring,as well as dysfunctions in the placenta are potential factors in the pathogenesis of GDM-associated pediatric NAFLD.In addition,potentially effective interventions for GDM-associated offspring NAFLD are also discussed in this review.However,most of these therapeutic approaches still require further clinical research for validation.

关 键 词：Gestational diabetes mellitus Nonalcoholic fatty liver disease Lipid metabolism Fetal development Nutrition therapy 

分 类 号：R714.256[医药卫生—妇产科学] R725.8[医药卫生—临床医学]