糖尿病视网膜病变房水细胞因子的研究进展  

Progress in the study of biological factors of aqueous humor in patients with diabetic retinopathy

作　　者：刘念恩 龙泽 徐小同 喻晓兵[1] Liu Nianen;Long Ze;Xu Xiaotong;Yu Xiaobing(Department of Ophthalmology,Beijing Hospital,National Center of Gerontology Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;the Fifth School of Clinical Medicine,Peking University,Beijing 100730,China)

机构地区：[1]北京医院眼科、国家老年医学中心、中国医学科学院老年医学研究院,北京100730 [2]中国医学科学院、北京协和医学院、北京协和医院眼科,北京100730 [3]北京大学第五临床医学院,北京100730

出　　处：《中华眼科杂志》2025年第3期221-229,共9页Chinese Journal of Ophthalmology

基　　金：中央高水平医院临床科研业务费专项(BJ-2022-175)。

摘　　要：糖尿病视网膜病变(DR)是糖尿病较常见的微血管并发症之一, 是糖尿病患者视力下降的主要原因, 炎性反应、氧化应激和血管功能障碍等病理过程在DR发病机制中发挥重要作用。在这些病理过程中相关细胞因子水平的变化与DR的发生、发展和程度相关。本文针对眼部房水中多种潜在的细胞因子在DR发病机制中的作用进行深入探讨, 以期发现可能诊疗DR的潜在靶点, 为开发新的治疗方法提供依据。Diabetic retinopathy(DR)is one of the most common microvascular complications of diabetes mellitus and a leading cause of vision loss in diabetic patients.Pathological processes such as inflammatory response,oxidative stress,and vascular dysfunction play important roles in the pathogenesis of DR.Changes in the levels of cytokines associated with these pathologic processes correlate with the onset,progression,and extent of DR.In this review,we address the role of various potential cytokines in aqueous humor in the pathogenesis of DR,with a view to identifying potential targets that may diagnose and treat DR and providing a basis for developing new therapeutic approaches.

关 键 词：糖尿病视网膜病变 眼房水 细胞因子类 

分 类 号：R58[医药卫生—内分泌]