流通池法在熊去氧胆酸片溶出研究中的应用  

Application of Flow-through Cell Method in the Dissolution Study of Ursodeoxycholic Acid Tablets

作　　者：朱文涛 董祥冬 黄秀娃 ZHU Wen-tao;DONG Xiang-dong;HUANG Xiu-wa(Jiangxi Kerui Pharmaceutical Co.,Ltd.,Ganzhou 341000,China)

机构地区：[1]江西科睿药业有限公司,江西赣州341000

出　　处：《海峡药学》2025年第2期19-23,共5页Strait Pharmaceutical Journal

摘　　要：目的 建立一种检查熊去氧胆酸片体外溶出的流通池方法。方法 采用不同原料药粒径制备的熊去氧胆酸片考察普通溶出方法和经优化的流通池方法,比较两种溶出方法的区分力。结果 普通溶出方法和流通池方法对高、中、低粒径制备的样品进行溶出测定,均表现出一定的溶出差异。结论 对于该品种的溶出检测,流通池法相比桨法具有更好的区分力,在前期处方研究中流通池法可作为辅助筛选方法。OBJECTIVE To establish a flow-through cell method for detecting the dissolution of ursodeoxycholic acid tablets in vitro.METHODS Ursodeoxycholic acid tablets prepared with different particle sizes of raw materials were used to investigate the conventional dissolution method and the optimized flow cell method,and the discrimination of the two dissolution methods was compared.RESULTS There was a certain difference in the dissolution of the samples prepared with high,medium and low particle size by the common dissolution method and the flow-through cell method.CONCLUSION Compared with the paddle method,the flow-through cell method has a better discrimination for the dissolution test of this variety,and it can be used as an auxiliary screening method in the previous prescription study.

关 键 词：熊去氧胆酸 流通池 药物溶出 区分力 

分 类 号：R927[医药卫生—药学]