二甲双胍和普伐他汀联合使用对机体血糖和血脂的影响  

Effects of the Co-administration of Metformin and Pravastatin on Blood Glucose and Blood Lipid

作　　者：王兴东[1] 李波霞[1] 马文帮 郭小冬[1] WANG Xing-dong;LI Bo-xia;MA Wen-bang;GUO Xiao-dong(Department of pharmacy,The first hospital of Lanzhou university,Lanzhou 730000,China;Department of pharmacy,Nuclear Industry 404 Hospital,Jiayuguan 735100,China)

机构地区：[1]兰州大学第一医院药剂科,甘肃兰州730000 [2]中核四○四医院药剂科,甘肃嘉峪关735100

出　　处：《海峡药学》2025年第2期32-35,共4页Strait Pharmaceutical Journal

基　　金：甘肃省自然科学基金(21JR7RA380);兰州大学第一医院青年基金(ldyyyn2020-77)。

摘　　要：目的 探究二甲双胍和普伐他汀合用后对血糖和血脂水平的影响及其机制。方法 收集我院2020年1月~2022年12月2型糖尿病和/或高血脂患者病例信息,对单用二甲双胍、单用普伐他汀和两药合用前后血糖和血脂数据统计分析,并在Wistar大鼠体内探究二甲双胍和普伐他汀的药动学相互作用。结果 联合用药后,普伐他汀并未影响二甲双胍的降血糖效果,但血脂指标TC和LDL-C的降低更为明显。动物实验显示,联合用药后普伐他汀血浆药物浓度无显著变化,而肝脏组织中的浓度升高。结论 二甲双胍通过增加普伐他汀肝脏浓度显著降低TC和LDL-C水平。OBJECTIVE To study the effects of the co-administration of metformin and pravastatin on blood glucose and blood lipid and their interaction mechanism.METHODS Cases of type 2 diabetes mellitus and/or hyperlipidemia were collected from our hospital during Jan.2020-Dec.2022 and data of blood glucose and blood lipid were analyzed after drugs administration,and the interaction mechanism of metformin and pravastation were evaluated in rats.RESULTS Pravastatin did not impact on the hypoglycemic effect of metformin.However,after combined use of metformin can significantly decrease the levels of TC and LDL-C.Animal experiments show that,after co-administration of metformin and pravastatin,there was no significant change in the plasma concentration of pravastatin,while the concentration of pravastatin in liver tissue significantly increased.CONCLUSION After co-administration of metformin and pravastatin,the decrease in TC and LDL-C levels may be related to the increased concentration of pravastatin in liver tissue after combined use of metformin.

关 键 词：二甲双胍 普伐他汀 药物相互作用 血糖 血脂 肝脏药物浓度 

分 类 号：R969.1[医药卫生—药理学]