1990—2021年全球和中国及不同社会人口学指数地区骨关节炎疾病负担趋势分析  

Disease Burden of Osteoarthritis in the World,China,and Regions with Different Sociodemographic Index from 1990 to 2021

作　　者：陈兴超 高振华 徐生刚[4] 邹永刚 钱军 魏建仝 CHEN Xingchao;GAO Zhenhua;XU Shenggang;ZOU Yonggang;QIAN Jun;WEI Jiantong(Department of Orthopedics,Zhangye People's Hospital Affiliated to Hexi University,Zhangye 734000,China;Institute of Bone and Joint Research,Hexi University,Zhangye 734000,China;Zhangye Orthopedics Quality Control Center,Zhangye 734000,China;Medical College,Hexi University,Zhangye 734000,China)

机构地区：[1]河西学院附属张掖人民医院骨科,甘肃省张掖市734000 [2]河西学院骨与关节研究所,甘肃省张掖市734000 [3]甘肃省张掖市骨科质量控制中心,734000 [4]河西学院医学院,甘肃省张掖市734000

出　　处：《中国全科医学》2025年第17期2172-2178,共7页Chinese General Practice

基　　金：甘肃省科技计划资助项目(25JRRG006);甘肃省卫生健康行业科研项目(GSWSQN2024-21);河西学院校长基金创新团队项目(CXTD002);河西学院校长基金青年科研项目(QN2024031)。

摘　　要：背景骨关节炎严重危害患者的身心健康,目前关于骨关节炎疾病负担的系统研究有限。目的分析1990—2021年全球、中国以及不同社会人口学指数(SDI)地区骨关节炎疾病的现状和疾病负担情况,从而制订和调整骨关节炎防护策略。方法基于2021年全球疾病负担数据库,提取1990—2021年全球、中国及不同SDI地区骨关节炎的发病率、患病率及伤残调整寿命年(DALYs)率及各标化率,采用平均年度变化百分比(AAPC)综合评价1990—2021年全球、中国及不同SDI地区骨关节炎疾病负担的变化趋势。结果全球骨关节炎的发病率、患病率和DALYs率分别从1990年的391.86/10万、4801.18/10万、167.22/10万上升至2021年的590.93/10万、7691.83/10万和269.97/10万。中国骨关节炎的发病率、患病率和DALYs率分别从1990年的395.61/10万、4535.01/10万、155.5/10万上升至2021年的641.62/10万、10743.18/10万和374.44/10万。2021年中国女性骨关节炎的发病率、患病率和DALYs率分别为1004.99/10万、13332.37/10万和465.35/10万,明显高于男性的641.62/10万、8272.97/10万和287.71/10万。1990—2021年全球骨关节炎的发病率、患病率和DALYs率呈增长趋势(AAPC=1.35%,95%CI=1.33%~1.37%;AAPC=1.54%,95%CI=1.52%~1.56%;AAPC=1.56%,95%CI=1.54%~1.59%)(P<0.05)。1990—2021年中国骨关节炎的发病率、患病率和DALYs率呈增长趋势(AAPC=2.47%,95%CI=2.36%~2.59%;AAPC=2.90%,95%CI=2.80%~3.00%;AAPC=2.94%,95%CI=2.85%~3.04%)(P<0.05)。1990—2021年全球、中国以及不同SDI地区骨关节炎的标化发病率、患病率和DALYs率呈上升趋势,且不同地区的骨关节炎疾病负担明显不同。结论1990—2021年全球、中国以及不同SDI地区骨关节炎的发病率、患病率和DALYs率呈增长趋势,疾病负担不断增加。此外,骨关节炎的疾病负担在不同地区、性别和年龄中存在较大差异。Background Osteoarthritis(OA)seriously endangers the physical and mental health of patients.Currently,systematic studies on the disease burden of OA are limited.Objective To analyze the current status and disease burden of OA disease in the world,China,and regions with different socio-demographic indexes(SDI)from 1990 to 2021,to formulate and adjust prevention strategies for OA.Methods The 2021 Global Burden of Disease database was used to analyze the incidence,prevalence,and disability-adjusted life years(DALYs)rates of OA in the world,China,and different SDI regions.The average annual percentage change(AAPC)was used to comprehensively evaluate the trend of OA burden in the world,China,and different SDI regions from 1990 to 2021.Results The global incidence,prevalence,and DALYs rate of OA increased from 391.86/100000,4801.18/100000,and 167.22/100000 in 1990 to 590.93/100000,7691.83/100000 and 269.97/100000 in 2021,respectively.The incidence,prevalence,and DALYs rate of OA in China increased from 395.61/100000,4535.01/100000,and 155.5/100000 in 1990 to 641.62/100000,10743.18/100000,and 374.44/100000 in 2021,respectively.In 2021,the incidence,prevalence,and DALYs rate of OA in females in China were 1004.99/100000,13332.37/100000,and 465.35/100000,respectively,which were significantly higher than 641.62/100000,8272.97/100000 and 287.71/100000 in males.The global incidence,prevalence,and DALYs rate of OA showed an increasing trend from 1990 to 2021(AAPC=1.35%,95%CI=1.33%-1.37%;AAPC=1.54%,95%CI=1.52%-1.56%;AAPC=1.56%,95%CI=1.54%-1.59%)(P<0.05).The incidence,prevalence,and DALYs rate of OA in China increased from 1990 to 2021(AAPC=2.47%,95%CI=2.36%-2.59%;AAPC=2.90%,95%CI=2.80%-3.00%;AAPC=2.94%,95%CI=2.85%-3.04%)(P<0.05).From 1990 to 2021,the standardized incidence,prevalence and DALYs rate of OA in the world,China,and different SDI regions showed an upward trend,and the disease burden of OA was significantly different in different regions.Conclusion The incidence,prevalence,and DALYs rate of OA is increasing globally,

关 键 词：骨关节炎 疾病负担 变化趋势 全球 中国 发病率 患病率 

分 类 号：R684.3[医药卫生—骨科学]