静脉滴注丙种球蛋白辅助治疗小儿糖尿病合并重症肺炎的有效性及安全性探讨  

Efficacy and Safety of Intravenous Infusion Gamma Globulin in Adjuvant Treatment of Children with Diabetes Mellitus Complicated with Severe Pneumonia

作　　者：苏立明 王艳丽 SU Liming;WANG Yanli(Children's Critical Care Center,Xiamen Children's Hospital(Children's Hospital of Fudan University at Xiamen),Xiamen 361006,Fujian,China;Department of Anesthesiology,Xiamen Children's Hospital(Children's Hospital of Fudan University at Xiamen),Xiamen 361006,Fujian,China)

机构地区：[1]厦门市儿童医院(复旦大学附属儿科医院厦门医院)儿童重症医学中心,福建厦门361006 [2]厦门市儿童医院(复旦大学附属儿科医院厦门医院)麻醉科,福建厦门361006

出　　处：《糖尿病新世界》2025年第1期13-15,19,共4页Diabetes New World

基　　金：厦门市自然科学基金项目(3502Z202374064)。

摘　　要：目的探讨静脉滴注丙种球蛋白治疗小儿糖尿病合并重症肺炎的效果及安全性。方法选取2022年9月—2024年3月厦门市儿童医院收治的60例糖尿病合并重症肺炎患儿,按治疗方法的不同分组。对照组(30例)接受常规治疗,观察组(30例)在对照组基础上静脉滴注丙种球蛋白。比较两组症状变化情况、血糖水平、临床疗效及不良反应发生率。结果观察组退热时间、咳嗽缓解时间、肺啰音消失时间和住院时间较对照组短,治疗后的空腹血糖、餐后2 h血糖、糖化血红蛋白水平较对照组低,差异均有统计学意义(P均<0.05)。观察组治疗总有效率较对照组高,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论常规对症治疗联合丙种球蛋白静脉滴注可提高糖尿病合并重症肺炎患儿的治疗效果,且用药安全性较高。Objective To investigate the efficacy and safety of intravenous gamma globulin in the treatment of children of diabetes mellitus complicated with severe pneumonia.Methods Sixty children with diabetes mellitus complicated with severe pneumonia admitted to Xiamen Children's Hospital from September 2022 to March 2024 were selected and divided into groups according to different treatment methods.The control group(30 cases)received routine treatment,and the observation group(30 cases)received intravenous infusion of gamma globulin on the basis of the control group treatment.The changes of symptoms,blood glucose levels,clinical efficacy and incidence of adverse reactions were compared between the children of two groups.Results The antipyretic time,cough relief time,lung rale disappearance time and hospitalization time in the observation group were shorter than those in the control group,the levels of fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c after treatment were lower than those in the control group,the differences were statistically significant(all P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Routine symptomatic treatment combined with intravenous infusion of gamma globulin can improve the treatment effectiveness of children with diabetes mellitus complicated with severe pneumonia,and the drug safety is high.

关 键 词：小儿糖尿病 重症肺炎 丙种球蛋白 有效性 安全性 

分 类 号：R725.8[医药卫生—儿科]