甘精胰岛素联合二甲双胍治疗初诊肥胖型2型糖尿病的疗效  

Efficacy of Insulin Glargine Combined with Metformin in the Treatment of Newly Diagnosed Obese Type 2 Diabetes Mellitus

作　　者：余慧莲 张丽玲 陈甜花 YU Huilian;ZHANG Liling;CHEN Tianhua(Department of Internal Medicine,Women and Children's Hospital Affiliated to Xiamen University(Xiamen Maternal and Child Health Hospital),Xiamen 361003,Fujian,China;Department of Clinical Laboratory,Women and Chil-dren's Hospital Affiliated to Xiamen University(Xiamen Maternal and Child Health Hospital),Xiamen 361003,Fu-jian,China)

机构地区：[1]厦门大学附属妇女儿童医院(厦门市妇幼保健院)内科,福建厦门361003 [2]厦门大学附属妇女儿童医院(厦门市妇幼保健院)医学检验科,福建厦门361003

出　　处：《糖尿病新世界》2025年第1期57-60,共4页Diabetes New World

摘　　要：目的分析甘精胰岛素与二甲双胍联合治疗初诊肥胖型2型糖尿病的效果。方法回顾性选取2021年2月—2024年8月在厦门大学附属妇女儿童医院接受诊疗的88例初诊肥胖型2型糖尿病的临床资料,根据治疗方法的不同分为联治组(n=44,二甲双胍联合甘精胰岛素治疗)、对照组(n=44,单纯二甲双胍治疗)。比较两组血糖水平、血脂水平、体重、体重指数、临床疗效及不良反应发生情况。结果治疗后,相比于对照组,联治组空腹血糖、餐后2 h血糖、甘油三酯、低密度脂蛋白胆固醇、总胆固醇、体重、体重指数更低,差异均有统计学意义(P均<0.05)。联治组临床疗效相比于对照组更高,差异有统计学意义(P<0.05)。对照组与联治组不良反应发生率比较,差异无统计学意义(P>0.05)。结论初诊肥胖型2型糖尿病患者利用甘精胰岛素与二甲双胍联合治疗,可有效控制患者血脂、血糖指标,整体效果优于单纯二甲双胍治疗,且安全性高。Objective To analyze the effect of insulin glargine combined with metformin in the treatment of newly diagnosed obese type 2 diabetes mellitus.Methods From February 2021 to August 2024,the clinical data of 88 newly diagnosed obese type 2 diabetes mellitus patients who were treated in the Women and Children's Hospital Affiliated to Xiamen University were retrospectively selected.According to the different treatment methods,they were divided into combined treatment group(n=44,metformin combined with insulin glargine treatment)and control group(n=44,simple metformin treatment).The blood glucose levels,blood lipid levels,body weight,body mass index,clinical efficacy and incidence of adverse reactions were compared between the two groups.Results After treatment,compared with the control group,fasting plasma glucose,2-hour postprandial plasma glucose,triglyceride,low density lipoprotein cholesterol,total cholesterol,body weight and body mass index were lower in the combined treatment group,and the differences were statistically significant(all P<0.05).The clinical efficacy of the combined treatment group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the control group and the combined treatment group(P>0.05).Conclusion The combination of insulin glargine and metformin in newly diagnosed obese patients with type 2 diabetes mellitus can effectively control the blood lipid and blood glucose indexes of patients.The overall effect is better than that of metformin alone,and the safety is high..

关 键 词：甘精胰岛素 二甲双胍 肥胖型2型糖尿病 血糖 血脂 

分 类 号：R587.1[医药卫生—内分泌]