Retinal Focus on Relationships between Diet-Induced, Advanced Glycation End Products and Supplemental Estradiol  

作　　者：Nicholas T.Bello Bonnie L.Firestein Maribel Vazquez 

机构地区：[1]School of Environmental and Biological Sciences,Department of Animal Sciences,Rutgers,The State University of New Jersey,New Brunswick,NJ 08901,USA [2]School of Arts and Sciences,Department of Cell Biology and Neuroscience,Rutgers,The State University of New Jersey,Piscataway,NJ 08854,USA [3]School of Engineering,Department of Biomedical Engineering,Rutgers,The State University of New Jersey,Piscataway,NJ 08854,USA

出　　处：《BIOCELL》2025年第3期349-354,共6页生物细胞(英文)

基　　金：funded by a Life Sciences Alliance Pilot Seed Grant from the Rutgers-New Brunswick Office of the Vice Provost for Research,Grant Number OVPR-100(MV)。

摘　　要：Neurodegeneration of retinal tissue leads to progressive vision loss in millions of working-age adults each year.Metabolic alterations caused by modern diets that are high in fats and sugars contribute to the development of diabetic retinopathy.Chronic,diet-induced metabolic changes are linked to high glucose and harmful,proinflammatory compounds in the blood,called advanced glycation end products(AGEs),that can alter the integrity of neurovascular barriers.AGEs-induced changes to the permeability of the inner blood-retinal barrier can lead to progressive vision loss with disparate impacts in patients with low estrogen,such as via natural aging processes,chronic illness,or aggressive medical interventions.Application of supplemental estradiol has been shown to ameliorate degeneration across the cardiovascular,intestinal,and nervous systems.This commentary describes the potential benefits of estradiol-based therapies on the visual health of older women with progressive diabetic retinopathy.

关 键 词：Muller glia endothelial cells HYPERGLYCEMIA diabetes 

分 类 号：R58[医药卫生—内分泌]